18319-92-1

Basic information

• Product Name: 4-METHYLUMBELLIFERYL HEPTANOATE
• Synonyms: HEPTANOIC ACID 4-METHYLUMBELLIFERYL ESTER;4-METHYLUMBELLIFERYL ENANTHATE;4-METHYLUMBELLIFERYL HEPTANOATE;4-MU-HEPTANOATE;heptanoicacid,4-methyl-2-oxo-2h-1-benzopyran-7-ylester;4-methyl-2-oxo-2H-1-benzopyran-7-yl heptanoate;4-METHYLUMBELLIFERYL ENANTHATE, FOR FLUO RESCENCE;4-MethylumbelliferylHeptanoateA.R.
• CAS NO: 18319-92-1
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288.34
• EINECS: 242-207-0
• Product Categories: Pharmaceutical Raw Materials;Substrates;substrate
• Mol File: 18319-92-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 41-42 °C(lit.)
• Boiling Point: 429°Cat760mmHg
• Flash Point: 214.5°C
• Appearance: /
• Density: 1.129g/cm³
• Vapor Pressure: 1.45E-07mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: −20°C
• BRN: 1256801
• CAS DataBase Reference: 4-METHYLUMBELLIFERYL HEPTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLUMBELLIFERYL HEPTANOATE(18319-92-1)
• EPA Substance Registry System: 4-METHYLUMBELLIFERYL HEPTANOATE(18319-92-1)

Safety Data

• WGK Germany: 3
• F: 8-10-21
• Hazardous Substances Data: 18319-92-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 18319-92-1 differently. You can refer to the following data:
1. 4-Methylumbelliferyl Heptanoate can be used as a biological indicator of sterilization.
2. Fluorogenic substrate for lipases.

InChI:InChI=1/C17H20O4/c1-3-4-5-6-7-16(18)20-13-8-9-14-12(2)10-17(19)21-15(14)11-13/h8-11H,3-7H2,1-2H3

Upstream product

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 2528-61-2 Heptanoic acid chloride 
• 5980-33-6 sodium 4-methylumbelliferonate 

Downstream Products

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 111-14-8 oenanthic acid 

Related news

Evaluation of 4-METHYLUMBELLIFERYL HEPTANOATE (cas 18319-92-1) as a substrate for oat lipase08/19/2019

The fluorogenic substrate 4-methylumbelliferyl heptanoate (MUH) has been reported to be suitable for measurement of lipase activity in cereal grains. In the present study, MUH hydrolysis was compared with a conventional lipase assay which measured the release of free fatty acids (FFA) from endog...detailed

Relevant articles and documents

Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives

By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A. (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted phenyl/2-thiophene rings are optimal in pharmacophore A and C. The optimized lead 4-methyl-9-phenyl-8-(thiophene-2-carbonyl)-furo[2,3-h] chromen-2-one (8g, IC50 = 70 nM) showed 64-fold enhanced activity compared to the high throughput screening (HTS) hit 6a. Also, 8g was found effective in case of influenza A (H3N2) and influenza B virus strains similar to approved anti-influenza drug zanamivir (4). Preliminary mechanistic studies suggest that these compounds act as anti-influenza agents by inhibiting ribonucleoprotein (RNP) complex associated activity and have the potential to be developed further, which could form the basis for developing additional defense against influenza pandemics.