5980-33-6

Basic information

• Product Name: 4-METHYLUMBELLIFERONE SODIUM SALT
• Synonyms: 4-methylumbelliferonesodium;7-hydroxy-4-methyl-2h-1-benzopyran-2-onesodiumsalt;7-hydroxy-4-methyl-2h-1-benzopyran-2-onsodiumsalt;7-hydroxy-4-methylcoumarinsodium;7-hydroxy-4-methyl-coumarisodiumsalt;cantabilinesodium;hymecromonesodium;lm94sodium
• CAS NO: 5980-33-6
• Molecular Formula: C₁₀H₇O₃*Na
• Molecular Weight: 198.15
• EINECS: 227-790-1
• Mol File: 5980-33-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 90-92 °C(lit.)
• Boiling Point: 377.4°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: yellow/crystalline
• Density: 1.319g/cm³
• Vapor Pressure: 3.11E-06mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-METHYLUMBELLIFERONE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLUMBELLIFERONE SODIUM SALT(5980-33-6)
• EPA Substance Registry System: 4-METHYLUMBELLIFERONE SODIUM SALT(5980-33-6)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: GN7570000
• Hazardous Substances Data: 5980-33-6(Hazardous Substances Data)

Usage

Uses

4-Methylumbelliferone Sodium Salt forms a complex with metals such as copper (II), zinc (II), nickel (II), cobalt (II) and iron (III) which displays spasmolytic activity. Also, it inhibits the hyaluronan acid in cultured human skin fibroblasts.

InChI:InChI=1/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3

Upstream product

• 126695-25-8 methyl (4-methyl-2-oxo-2H-1-benzopyran-7-yl 4,5,7,8,9-penta-O-acetyl-3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 126695-26-9 C₁₉H₂₂O₁₁ 

Downstream Products

• 92574-74-8 4-methylcoumarin-7-yloxy tridecaacetyl-β-chitotetraoside 
• 123269-92-1 benzyl (4-methylumbelliferonyl 4,5,7,8,9-penta-O-acetyl-3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 59322-44-0 4--methylcoumarin--7--yl 5--acetamido--3,5--dideoxy-α---D--glycero--D--galacto-2-nonulopyranosidonic acid 
• 18319-92-1 4-Methylumbelliferyl heptanoate 
• 629-62-9 pentadecane 
• 1228931-52-9 4-methylumbelliferyl 3,6-di-O-acetyl-2-deoxy-2-acetamido-4-O-(3,6-di-O-acetyl-2,4-dideoxy-2-acetamido-β-D-glucopyranosyl)-β-D-glucopyranoside 
• 18319-93-2 4-methylumbelliferyl nonanoate 
• 20671-66-3 7-(heptylcarbonyl)oxy-4-methyl-2H-1-benzopyran-2-one 
• 123269-95-4 sodium (4-methylumbelliferonyl 3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 53643-13-3 4-methylumbelliferyl β-D-N,N′,N′′-triacetylchitotrioside 
• 137215-27-1 7-mercapto-4-methyl-2H-chromen-2-one 
• 6160-80-1 4-methylumbelliferyl-β-D-glucuronide 
• 6160-81-2 (2S,3R,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid 
• 28541-83-5 4-methylumbellifer-7-yl α-D-mannopyranoside 

Relevant articles and documents

A Mechanistic Study on the Non-enzymatic Hydrolysis of Kdn Glycosides

Sialic acids are biologically important carbohydrates that are prevalent throughout nature. We are interested in their intrinsic reactivity in aqueous solution and how such reactivity affects the design of substrates for investigation of enzymes that process these sugars. To probe the reactivity differences between two sialic acid family members N-acetylneuraminic acid and Kdn we measured the rate constants for hydrolysis of 4-nitrophenyl 3-deoxy-d-glycero-α-d-galacto-non-2-ulosonide in aqueous solution. The kinetic data is consistent with glycosidic C?O bond cleavage occurring via four mechanistic pathways, and these are: (i) hydronium ion-catalyzed hydrolysis of the neutral sugar; (ii) hydronium ion-catalyzed hydrolysis of the glycosidic carboxylate; (iii) water-catalyzed hydrolysis of the anionic glycoside; and (iv) base-promoted reaction of the anionic glycoside. To study the effects of C-5 substitution on the Kdn glycoside we made 4-nitrophenyl 5-O-methyl-α-Kdn glycoside and determined its rate constants for hydrolysis. All hydrolytic rate constants for both Kdn glycosides were larger than those reported for the parent N-acetyl-α-neuraminide. The water-catalyzed reaction (pathway iii) exhibited a βlg value of ?1.3±0.1. We conclude that the larger rate constants associated with C5-oxygen containing sialosides results from less steric congestion at the hydrolytic transition states than for the parent C-5 acetamido glycoside.