1832-88-8Relevant articles and documents
A PREGNANE ESTER DIGLYCOSIDE FROM PERIPLOCA CALOPHYLLA
Deepak, Desh,Khare, Maheshwari P.,Khare, Anakshi
, p. 3015 - 3018 (1985)
A new pregnane ester diglycoside of ornogenin named as plocinine was isolated from the dried twigs of Periploca calophylla.On the basis of chemical and spectroscopic evidences its structure was established as 12,20-di-O-cinnamoyl sarcostin-3-O-α-L-oleandr
Studies on the constituents of Asclepiadaceae plants. XXXII. Aglycones from Cynanchum wilfordi Hemsley
Hayashi,Mitsuhashi
, p. 139 - 143 (1975)
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Four new pregnane glycosides from Gymnema latifolium and their α-glucosidase and α-amylase inhibitory activities
Yen, Duong Thi Hai,Trang, Do Thi,Tai, Bui Huu,Doan, Vu Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Van Minh, Chau,Hoang Duc, Manh,Park, SeonJu,Hyuk Lee, Jae,Kim, Sun Yeou,Kim, Seung Hyun,Kiem, Phan Van
supporting information, p. 4460 - 4467 (2020/03/03)
Four new pregnane glycosides, gymlatifosides A - D (1 ? 4) and one known pregnane glycoside, verticilloside J (5) were isolated from the leaves of Gymnema latifolium Wall. ex Wight. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, HR-ESI-MS, and in comparison with the reported data. All these compounds were tested for α-glucosidase and α-amylase inhibitory activities. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 37.8 ± 1.5% at the concentration of 200 μM. Compounds 1–4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 7.0 to 30.1%. In addition, all compounds 1–5 showed moderate/weak anti α-amylase activity in the investigated test.
The anti-glycative potentials of pregnane glycosides from Gymnema sylvestre
Hung, Nguyen Van,Kiem, Phan Van,Kim, Seung Hyun,Kim, Sun Yeou,Lee, Jae Hyuk,Manh, Hoang Duc,Minh, Chau Van,Nhiem, Nguyen Xuan,Park, SeonJu,Tai, Bui Huu,Trang, Do Thi,Yen, Duong Thi Hai,Yen, Pham Hai
, p. 19 - 24 (2020/05/18)
Gymnema sylvestre is known for its potent antidiabetic activity. Phytochemical investigations of this plant led to the isolation of three new pregnane glycosides, gymnepregosides R-T (1-3) and four known analogues, 12β-acetyloxy-3β,8β,14β,17β-tetrahydroxypregn-5-en-20-one 3-O-β-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (4), 12-O-(E)-cinnamoylgymnepregoside F (5), gymnepregoside F (6), and stephanoside I (7). Their structures were identified based on spectroscopic evidence and compared with those reported in the literature. All compounds were evaluated for antiglycative inhibitory activity. Compounds 1, 3, 5, and 6 showed the inhibitory effect on BSA-MGO formation ranging from 6.0 to 8.8 % at the concentrations of 400 μM. Compounds 1 and 2 showed significant breaking properties on MGO-AGE-protein crosslink with percent modification ranging from 54.6 to 58.4 %. Notably, a novel AGEs inhibitor (1) may inhibit the formation and accumulation of MGO-AGEs and protect cells from MGO-AGEs cross-linking damage.
