183200-95-5Relevant academic research and scientific papers
Design of β-amino alcohols as chiral auxiliaries in the electrophilic amination of 1,3,2-oxazaphospholanes
Pagliarin, Roberto,Papeo, Gianluca,Sello, Guido,Sisti, Massimo,Paleari, Lino
, p. 13783 - 13794 (1996)
Theoretical studies to predict the diastereoselectivity of the electrophilic amination of chiral 1,3,2-oxazaphospholanes led to the design of (1R), (2S)-1,3-diphenyl-2-(N-isopropylamino)-1-propanol 7 as a powerful chiral auxiliary. The experimental results are in good agreement with the calculations. An efficient synthesis of enantiomerically pure 7 is also reported.
