183206-53-3

Upstream product

• 75-03-6 ethyl iodide 
• 183206-51-1 tert-butyl benzyl(cyclopropyl)carbamate 
• 132844-48-5 Cyclopropylcarbamic acid t-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 183206-61-3 (4-Chloro-1-ethyl-1-phenyl-butyl)-cyclopropyl-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Lithiation-substitutions of N-Boc N-alkyl cyclopropylamines

A series of lithiation-substitution reactions at the α and β positions of N-Boc N-alkyl cyclopropyl amines is reported. The cyclopropane ring is the preferred position for lithiation in the N-ethyl and N-methyl derivatives 6 and 7, but the N-allyl and N-benzyl derivatives 8 and 9 undergo lithiation at the methylene groups. Lithiations at β positions of the cyclopropylamine ring are observed if the α-position is blocked or the β-positions are activated by phenyl substitution as shown for the reactions of 10, 15 and 21. Both α and β lithiations can be used in lithiation-cyclization reactions to provide the bicyclic spiro or endo fused N-Boc amines 15, 16 and 25. Lithiations of N-Boc-4-tosyloxy piperidine 30 with s-BuLi/(-)-sparteine followed by trimethylsilyl chloride give the N-Boc azabicyclo[3.1.0] hexane 32 with enantiomeric excesses which range from 18-55%. Two β-carbomethoxy substituted N-Boc cyclopropylamines 18 and 26 can participate in a formal [3 + 2] cycloaddition with tetracyanoethylene to give substituted cyclopentanes.