183208-38-0Relevant articles and documents
NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7
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Page/Page column 40, (2009/10/17)
The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.
Synthesis of 7-azaserotonin: Its photophysical properties associated with excited state proton transfer reaction
Wu, Pei-Wen,Hsieh, Wan-Ting,Cheng, Yi-Ming,Wei, Ching-Yen,Chou, Pi-Tai
, p. 14426 - 14427 (2008/01/27)
We report the synthesis of 3-(2-aminoethyl)-5-ol-1H-pyrrolo[2,3-b]pyridine (7-azaserotonin), which may potentially serve as an agonist or antagonist of serotonin receptors. In alcohols, the solvent (e.g., ethanol) catalyzed proton-transfer reaction takes place for 7-azaserotonin in the excited state, resulting in dual emission. Conversely, excited-state deprotonation takes place in neutral aqueous solution. The unique excitation behavior makes 7-azaserotonin versatile as a potential bioprobe. Copyright
PPAR ACTIVE COMPOUNDS
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Page 158-159, (2008/06/13)
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Synthesis of new melatoninergic ligands including azaindole moiety
Mazéas, Daniel,Guillaumet, Gérald,Viaud, Marie-Claude
, p. 1065 - 1080 (2007/10/03)
A novel series of melatonin analogues, based on the azaindole nucleus is described. These compounds are prepared in several steps directly from the commercial available 7-azaindole or from substituted amino-, iodo- or/and nitropyridines using a catalysed palladium reaction or vicarious nucleophilic substitution of hydrogen (VNS) in order to elaborate the 6-, 5- and 4- azaindole derivatives respectively.