183208-36-8

Basic information

• Product Name: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE;5-METHOXY-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine,5-methoxy-(9CI);1H-Pyrrolo[2,3-b]pyridine, 5-methoxy-;5-Metho×y-1H-pyrrolo[2,3-b]pyridine;5-Methoxyl-7-azaindole;5-METHOXY-1H-PYRROLO[2,3-B]PYR;5-methoxy-1H-pyrrolopyridine
• CAS NO: 183208-36-8
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Product Categories: PYRIDINE;Azaindoles
• Mol File: 183208-36-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 412.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.24
• Refractive Index: 1.647
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.24±0.20(Predicted)
• CAS DataBase Reference: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(183208-36-8)
• EPA Substance Registry System: 5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE(183208-36-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 183208-36-8(Hazardous Substances Data)

Usage

Chemical Properties

Tan solid

InChI:InChI=1/C8H8N2O/c1-11-7-4-6-2-3-9-8(6)10-5-7/h2-5H,1H3,(H,9,10)

Upstream product

• 779345-37-8 5-fluoro-2-nitro-pyridine 
• 39856-50-3 5-bromo2-nitropyridine 
• 52092-47-4 5-chloro-2-nitropyridine 
• 1826-67-1 vinyl magnesium bromide 
• 126739-64-8 3-methoxy-6-nitropyridine 
• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 1101060-84-7 2-amino-3-methyl-5-methoxypyridine 
• 10592-27-5 7-azaindoline 
• 754214-54-5 5-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-pyrrolo[2,3-b]pyridine 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 

Downstream Products

• 916895-89-1 7-azaserotonin 
• 1312017-98-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclohexyl-ethanol 
• 1312018-13-5 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-ethanol 
• 1312018-29-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-furan-2-yl)-ethanol 
• 1312019-37-6 (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol 
• 1235865-77-6 [2-((1H-pyrrolo [2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid] 
• 1235865-76-5 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid methyl ester 
• 1257044-57-7 methyl (2-((1H-pyrrole[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1-yl))benzoate 
• 1257044-40-8 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 

Relevant articles and documents

Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection

We report the synthesis and pharmacological evaluation of new 3-aminomethylindoles derivatives with neuroprotective properties designed to present multi-target activity centered on reducing the neuronal Ca2+ overload and preventing phosphatase

Preparation method 5- hydroxyl -7- azaindole (by machine translation)

The invention discloses 5 -hydroxy- 7 7-azaindole preparation method, which takes 5 - X - 2 -nitropyridine as a raw material to react with benzyl alcohol sodium or sodium alkyl sodium alkoxide to generate 5 - R - 2 -nitropyridine, which is benzyl, methyl or ethyl X after being closed by a Grignard reagent ring after cyclization is carried, out, and ;R is high, yield. (by machine translation)

PROCESS FOR THE PREPARATION OF VENETOCLAX

The present disclosure provides novel synthetic process for the preparation of venetoclax. The disclosed processes involve the use of novel intermediates. Processes for the preparation of these intermediates are also disclosed as well as methods for the preparation of particularly useful salts thereof.