18325-52-5

Upstream product

• 707-60-8 4-bromo-N,N-dimethylbenzenesulfonamide 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 383-31-3 4-fluoro-1-(N,N-dimethylaminosulfonyl)benzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 677782-39-7 4-(N,N-dimethylsulfamoyl)benzene-1-sulfonyl chloride 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS TRPML MODULATORS

The new piperazine derivatives are modulators of TRPML and are useful in treating disorders related to TRPML activities such as lysosome storage diseases, muscular dystrophy, age-related common neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS) related diseases, and ageing.

METHYLAMINE DERIVATIVES AS LYSYSL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER

Provided are compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, wherein W, X, Y, Z, x, R1, R2, R3, x and n are defined in the specification. The compounds are inhibitors of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family members (LOXL1, LOXL2, LOXL3, LOXL4) and are useful in therapy, particularly in the treatment of cancer. Also disclosed are LOX inhibitors for use in the treatment of a cancer associated with EGFR and biomarkers that predict responsiveness to a LOX inhibitor.