183271-30-9

Upstream product

• 183271-28-5 [2-(3,6-Diamino-9H-xanthen-9-yl)-phenyl]-methanol 
• 1062751-70-5 rhodamine 110 
• 183271-29-6 Acetic acid 2-(3,6-bis-acetylamino-9H-xanthen-9-yl)-benzyl ester 

Downstream Products

• 183271-31-0 N-{6-Acetylamino-9-[2-(2-hydroxy-ethoxymethyl)-phenyl]-9H-xanthen-3-yl}-acetamide 
• 183271-37-6 Acetic acid 2-[2-(3,6-bis-acetylamino-9H-xanthen-9-yl)-benzyloxymethoxy]-ethyl ester 
• 183271-38-7 N-{6-Acetylamino-9-[2-(2-hydroxy-ethoxymethoxymethyl)-phenyl]-9H-xanthen-3-yl}-acetamide 

Relevant academic research and scientific papers

Rhodanol Synthons for Fluorescent Labeling and Drug Conjugates

The synthesis of Rhodanol derivatives 1b-1j is described.Rhodamine 123 was reduced to the corresponding alcohol and after acetylation of the amino functionalities, the protected Rhodanol was further derivatized by alkylation with oxirane, chloromethyloxirane and 2-acetoxyethoxymethylchloride.The coupling of some synthons to FU and FUrd at different conditions was studied.Synthons 1a, 1b and 1f were converted to phosphoramidites and used for 5'-labeling of oligonucleotides as a final step in solid-phase synthesis on automated DNA synthesizer.