183271-31-0Relevant academic research and scientific papers
Rhodanol Synthons for Fluorescent Labeling and Drug Conjugates
Spassova, Maria,Kois, Pavol,Watanabe, Kyoichi
, p. S290 - S293 (2007/10/03)
The synthesis of Rhodanol derivatives 1b-1j is described.Rhodamine 123 was reduced to the corresponding alcohol and after acetylation of the amino functionalities, the protected Rhodanol was further derivatized by alkylation with oxirane, chloromethyloxirane and 2-acetoxyethoxymethylchloride.The coupling of some synthons to FU and FUrd at different conditions was studied.Synthons 1a, 1b and 1f were converted to phosphoramidites and used for 5'-labeling of oligonucleotides as a final step in solid-phase synthesis on automated DNA synthesizer.
