183279-02-9

Upstream product

• 88091-70-7 1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride 
• 183279-01-8 4-amino-6,7-dimethyl-1-(2-deoxy-β-D-ribofuranosyl)pteridine-2-one 
• 199789-64-5 4-Amino-6,7-dimethyl-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pteridin-2-one 
• 183279-00-7 C₂₉H₂₈N₄O₆S 
• 199789-51-0 [6,7-Dimethyl-2-oxo-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pteridin-4-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 50256-07-0 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione 

Downstream Products

• 183279-03-0 (1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-dimethyl-2-oxo-1,2-dihydro-pteridin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 

Relevant academic research and scientific papers

Pteridine nucleosides - New versatile building blocks in oligonucleotide synthesis

Chemical syntheses of 1-(2-deoxy-β-D-ribofuranosyl)lumazines and isoptefins as well as 8-(2-deoxy-β-D-ribofuranosyl)-4-amino-7(8H)pteridones and -isoxantho-pterins have been developed to make the structural analogs of the naturally occurring 2'-deoxyribonucleosides in the pteridine series available. The corresponding phosphoramidites have been used in machine- aided solid-support syntheses leading to new types of fluorescence labeled oligonucleotides. The effects of the various fluorophors on duplex formation and as labels for enzyme reactions is demonstrated.

Synthesis of Mixed Oligonucleotides Containing 6,7-Dimethylisopterin as Modified Aglycone

6,7-Dimethyl-1-(2-deoxy-β-D-ribofuranosyl)isopterin 3 was prepared from 6,7-dimethyl-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)lumazine via thiation and displacement of the thio function with ammonia.It was then converted into the corresponding N4-benzoyl and N4-p-nitrophenylethoxycarbonyl phosphoramidite building blocks.Mixed oligonucleotides containing 6,7-dimethylisopterin as a modified base were synthesised using solid phase phosphoramidite strategy.