50256-07-0

Basic information

• Product Name: 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione
• CAS NO: 50256-07-0
• Molecular Weight: 544.564
• Mol File: 50256-07-0.mol

Chemical Properties

• CAS DataBase Reference: 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione(50256-07-0)
• EPA Substance Registry System: 1-[O³,O⁵-bis-(4-methyl-benzoyl)-β-D-erythro-2-deoxy-pentofuranosyl]-6,7-dimethyl-1H-pteridine-2,4-dione(50256-07-0)

Safety Data

• Hazardous Substances Data: 50256-07-0(Hazardous Substances Data)

Upstream product

• 3601-89-6 Hoffer's chlorosugar 
• 5774-32-3 6,7-dimethyllumazine 

Downstream Products

• 183279-00-7 C₂₉H₂₈N₄O₆S 
• 183279-02-9 [1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6,7-dimethyl-2-oxo-1,2-dihydro-pteridin-4-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 183279-03-0 (1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-dimethyl-2-oxo-1,2-dihydro-pteridin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 199789-51-0 [6,7-Dimethyl-2-oxo-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pteridin-4-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 183279-05-2 4-Amino-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-dimethyl-1H-pteridin-2-one 
• 183279-06-3 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6,7-dimethyl-2-oxo-1,2-dihydro-pteridin-4-yl)-benzamide 
• 159228-05-4 1-(2,3-dideoxy-5-O-p-toluoyl-β-D-glycero-pentofuranosyl)-6,7-dimethyllumazine 
• 159228-03-2 1-(2-deoxy-5-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine 
• 159228-04-3 1-(2,3-dideoxy-3-iodo-5-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine 

Relevant articles and documents

Nucleosides. LIV. Synthesis and properties of 3'-azido- and 2',3'-dideoxy- 6,7-diphenyllumazine nucleosides

The best approach for the synthesis of 1-(3-azido-2,3-dideoxy-β-D- erythro-pentofuranosyl)lumazine (5) and its 6,7-dimethyl- (4) and 6,7- diphenyl derivatives (3) has been found in the interconversion of the corresponding 1-(2-deoxy-β-D-threo-pentofuranosyl)-lumazines. Monomethoxytritylation at the 5'-position (17, 34, 49) followed by mesylation at the 3'-OH group and subsequent nucleophilic displacement by lithium azide afforded 19, 29 and 47 which were deprotected by acid treatment to give 3-5 in good yields. The syntheses of 1-(2,3-dideoxy-β-D-glycero- pentofuranosyl)- 6,7-diphenyllumazine (6) and its 6,7-dimethyl derivative (7) were achieved from 1-(2-deoxy-β-D-erythro-pentofuranosyl)- 6,7- diphenyllumazine and the corresponding 6,7-dimethyllumazine (26) via their 5'-O-p-toluoyl- (20, 30), and 3'-deoxy-3'-iodo derivatives (24, 31) to form, after radical dehalogenation and final deprotection, 6 and 7. The newly synthesized lumazine nucleosides have been characterized by elemental analyses, UV- and NMR spectra.