183282-56-6Relevant academic research and scientific papers
Optically active 5-(hydroxyalkyl)- and 5-(aminoalkyl)pyrazolidin-3-ones by ring-chain transformation of α,β-unsaturated lactones or lactams with hydrazines
Bohrisch, Joerg,Faltz, Heike,Paetzel, Michael,Liebscher, Juergen
, p. 1581 - 1585 (1996)
α,β-Unsaturated lactones or lactams 1 react with hydrazines 2 via Michael-like addition and subsequent ring transformation by nucleophilic attack of the hitherto unchanged hydrazine nitrogen atom at the carbonyl carbon atom. The addition is highly trans-stereoselective, thus affording optically active hydroxylalkyl- or aminoalkylpyrazolidin-3-ones 4 and 6. These pyrazolidin-3-ones are further transformed to tosylated, acetylated or silylated derivatives 9 or react with benzaldehyde to give the azomethine imine 10. VCH Verlagsgesellschaft mbH, 1996.
A novel synthesis of tetrahydropyrazolo[1,5-c]pyrimidine-2,7(1 H,3 H)-diones
Mirnik, Jona,Gro?elj, Uro?,Novak, Ana,Dahmann, Georg,Golobi?, Amalija,Kasuni?, Marta,Stanovnik, Branko,Svete, Jurij
, p. 3404 - 3412 (2014/01/06)
A novel simple five-step synthesis of 1,6-disubstituted tetrahydropyrazolo[1,5-c]pyrimidine-2,7(1H,3H)-diones has been developed. The synthetic protocol starts with 'ring switching' transformation of commercially available 5,6-dihydro-2H-pyran-2-one into
