18329-25-4

Upstream product

• 6553-64-6 6,6-Dimethyl-2-cyclohexen-1-one 
• 1193-47-1 2,2-dimethyl-cyclohexanone 
• 75-26-3 isopropyl bromide 
• 21690-26-6 6-bromo-2,2-dimethylcyclohexan-1-one 
• 18329-20-9 3,3,7,7-tetramethylbicyclo<4.1.0>hept-4-en-2-one 

Relevant academic research and scientific papers

Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade

We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the need for strong acids or bases. Both cyclic and acyclic ketones, as well as α-branched aldehydes, are suitable substrates for coupling with secondary and tertiary alkyl bromides. Concise formal synthesis of Zanapezil is achieved using this β-alkylation method.