1833-44-9Relevant academic research and scientific papers
Benzylic Grignard Reagents: Application of (thf = tetrahydrofuran) in Regioselective Grignard Formation and C-O Cleavage in Benzyl Ethers
Gallagher, Michael J.,Harvey, Stephen,Raston, Colin L.,Sue, Rodney E.
, p. 289 - 290 (2007/10/02)
Benzylic Grignard reagents (2)-(4), bearing ortho- and para-halogeno ring substituents, are readily accessible by treating the corresponding benzylic halide with (1) in tetrahydrofuran (thf); o- and p-chloromethyl(methoxymethyl)benzenes with (1) rapidly yield 'di-Grignards' whereas the meta-isomer only affords a mono-Grignard' (5), and bis(methoxymethyl)benzenes slowly undergo C-O cleavage, (6).
Substitution electrophile originale (en position benzylique), avec le benzyltrimethylsilane
Bordeau, Michel,Villeneuve, Patrice,Bennetau, Bernard,Dunogues, Jacques
, p. 169 - 174 (2007/10/02)
Benzyltrimethylsilane reacts with iodine monobromide, bromine in the presence of iodine as catalyst, or bromine under electrophilic substitution either on the aromatic ring or at the benzylic position.The for the first time observed direct benzylic substi
