183382-76-5

Basic information

• Product Name: N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide
• Synonyms: N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide
• CAS NO: 183382-76-5
• Molecular Weight: 539.291
• Mol File: 183382-76-5.mol

Chemical Properties

• CAS DataBase Reference: N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide(183382-76-5)
• EPA Substance Registry System: N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide(183382-76-5)

Safety Data

• Hazardous Substances Data: 183382-76-5(Hazardous Substances Data)

Upstream product

• 40054-01-1 (6-(bromomethyl)pyridin-2-yl)methanol 
• 70-55-3 toluene-4-sulfonamide 
• 183382-74-3 N,N-bis[[6-(hydroxymethyl)pyridine-2-yl]methyl]-p-tosylamide 

Downstream Products

• 115078-42-7 N,N',N''-tri-p-tosyl-2,11,20-triaza<3.3.3>(2,6)pyridinophane 

Relevant articles and documents

Improved synthesis of a C3-symmetrical pyridinophane

The formation of the C3-symmetrical 2,11,20-triaza[3.3.3](2,6)pyridinophane 1 was undertaken with the aim of improving the synthesis of this highly desirable macrocycle, with the future aim of functionalizing 1 with amide pendent arms for the recognition of lanthanide ions. The synthesis of 1 involves the stepwise transformation of pyridine-2,6-dicarboxylic acid into two key intermediates; N,N-bis[(6-hydroxymethyl)pyridin-2-yl]-p-tosylamide 7 and 6-bis[(amino-p-tosyl)methyl]pyridine 5. The macrocyclization of these two intermediates gave 8, from which 1 was formed upon deprotection of the three tosyl groups.