40054-01-1

Basic information

• Product Name: 2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE
• Synonyms: bromomethylpyridinemethanol;2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE;6-(BROMOMETHYL)-2-PYRIDINEMETHANOL;(6-BROMOMETHYL-PYRIDIN-2-YL)METHANOL;6-(Bromomethyl)-2-(hydroxymethyl)pyridine
• CAS NO: 40054-01-1
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.05
• Mol File: 40054-01-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 284.122 °C at 760 mmHg
• Flash Point: 125.633 °C
• Appearance: /
• Density: 1.604 g/cm³
• Vapor Pressure: 0.00143mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE(40054-01-1)
• EPA Substance Registry System: 2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE(40054-01-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 40054-01-1(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)-6-(hydroxymethyl)pyridine is a chemical compound that contains a pyridine ring with a bromomethyl group at the 2-position and a hydroxymethyl group at the 6-position. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon bonds. 2-(BROMOMETHYL)-6-(HYDROXYMETHYL)PYRIDINE is also a versatile building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential as an antiviral, antifungal, and antibacterial agent. Additionally, 2-(bromomethyl)-6-(hydroxymethyl)pyridine has shown promise as a reagent in the preparation of functionalized heterocycles and other complex organic molecules.

InChI:InChI=1/C7H8BrNO/c8-4-6-2-1-3-7(5-10)9-6/h1-3,10H,4-5H2

Upstream product

• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 

Downstream Products

• 183382-74-3 N,N-bis[[6-(hydroxymethyl)pyridine-2-yl]methyl]-p-tosylamide 
• 1131605-11-2 [6-(fluoromethyl)pyridin-2-yl]methanol 
• 1225014-61-8 2-[3-(2-hydroxymethyl-6-pyridylmethoxy)-6-methoxy-9H-xanthen-9-yl]benzoic acid methyl ester 
• 115521-06-7 Methanesulfonic acid 6-[3-(6-methanesulfonyloxymethyl-pyridin-2-ylmethylsulfanylmethyl)-benzylsulfanylmethyl]-pyridin-2-ylmethyl ester 
• 183382-76-5 N,N-bis[[6-(bromomethyl)pyridine-2yl]methyl]-p-tosylamide 

Relevant articles and documents

Convenient and Multistep Preparation of Oligopyridines Bearing Multiple Dansyl and Nitroxide Radicals

A series of pyridine and bipyridine molecules combining dual fluorescent (dansyl) and magnetic (free radical) probes has been prepared by a linear multistep protocol from the corresponding monodansylated derivatives. The grafting of the flexible aliphatic radical is realized by the use of a chloromethylnitronyl nitroxide derivative under basic conditions and with KI as a mediator. The synthetic potential of 2-[(5-dimethylamino-1-naphthalenesulfonamide)methyl]-6-formylpyridine is assessed by the construction, in a first step, of an aliphatic nitroxide radical and subsequently of an additional aromatic radical. The synthetic methods reported herein provide a practical approach to the rational design of ligands bearing various kinds of functionalities such as chromogenic and spinlabeled fragments. A significant merit of this method is that it allows the introduction of the fluorescent substituent onto the pyridine or bipyridine framework at the beginning of the synthetic protocol.

Syntheses of zinc complexes with multidentate nitrogen ligands: New catalysts for aldol reactions

The ligands 2,6-bis{[(pyrid-2-ylmethyl)amino]methyl}-pyridine with an N5 pattern and (6-{[(pyrid-2-ylmethyl)amino]methyl}pyrid-2-yl)methanol with an N3O pattern were synthesized. ZnII complexes of the two ligands could be obtained, and the single-crystal X-ray structure of (2,6-bis{[(pyrid-2-ylmethyl)amino]methyl}pyridine)zinc chloride showed Zn coordination to all five nitrogen atoms. The strong complexation of 2,6-bis{[(pyrid-2-ylmethyl)-amino]methyl}pyridine and (6-{[(pyrid-2-ylmethyl)amino]-methyl}pyrid-2-yl)methanol with ZnII were demonstrated by 1H NMR spectroscopic studies and electrospray mass spectrometry. The coupling of 2-hydroxyacetophenone and benzaldehyde was studied in the presence of the prepared Zn complexes, and it was shown that the coupling product was obtained at room temperature in up to 60% yield with 7.5 mol% of the zinc catalyst. The present complexes mimic the active site of the zinc-dependent class II aldolases, where ZnII is coordinated to three nitrogen atoms. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.