183387-10-2

Upstream product

• 183387-05-5 4-Nitro-benzoic acid (3S,4S)-4-benzyloxy-tetrahydro-furan-3-yl ester 
• 183387-01-1 (S)-5-Oxo-tetrahydro-furan-2-carboxylic acid (3R,4S)-4-benzyloxy-tetrahydro-furan-3-yl ester 
• 180074-56-0 N,N-Dibutyl-N'-(9H-purin-6-yl)-formamidine 
• 183387-07-7 (3S,4S)-4-benzyloxy-tetrahydro-furan-3-ol 
• 130931-97-4 (-)-(3R,4S)-4-benzyloxytetrahydrofuran-3-ol 

Relevant academic research and scientific papers

Tetrahydrofuran Ring-Containing Nucleotide Analogs Related to HPMPA and PMEA

Synthesis of 9-N-(4-(phosphonomethoxy)tetrahydrofuran-3-yl)adenine derivatives, a novel type of nucleotide analogs related to (R)- and (S)-9-N-(3-hydroxy-2-phosphonomethoxypropyl)adenine ((R)- and (S)-HPMPA) and 9-(2-phosphonomethoxyethyl)adenine (PMEA), is described.The synthesis of adenine nucleotide analogs 6a-6d is based on the reaction of 6-N-protected adenine derivatives 5a-5d with diisopropyl tosyloxymethanephosphonate and subsequent deprotection of resulting compounds.The starting "nucleoside" derivatives have been prepared from chiral 4-benzyloxytetrahydrofuran-3-ols 3a-3d.