183387-07-7Relevant academic research and scientific papers
Process for the preparation of trans-3-alkyloxy-4-hydroxytetrahydrofuran
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, (2008/06/13)
Disclosed is a process for preparing novel trans-3-alkyloxy-4-hydroxytetrahydrofurans including racemic and substantially enantiomerically pure (3S,4S)-trans-3-alk(en)yloxy-4-hydroxytetrahydrofurans and (3R,4R)-trans-3-alk(en)yloxy-4-acyloxytetrahydrofura
Tetrahydrofuran Ring-Containing Nucleotide Analogs Related to HPMPA and PMEA
Liboska, Radek
, p. S72 - S75 (2007/10/03)
Synthesis of 9-N-(4-(phosphonomethoxy)tetrahydrofuran-3-yl)adenine derivatives, a novel type of nucleotide analogs related to (R)- and (S)-9-N-(3-hydroxy-2-phosphonomethoxypropyl)adenine ((R)- and (S)-HPMPA) and 9-(2-phosphonomethoxyethyl)adenine (PMEA), is described.The synthesis of adenine nucleotide analogs 6a-6d is based on the reaction of 6-N-protected adenine derivatives 5a-5d with diisopropyl tosyloxymethanephosphonate and subsequent deprotection of resulting compounds.The starting "nucleoside" derivatives have been prepared from chiral 4-benzyloxytetrahydrofuran-3-ols 3a-3d.
Enzymic Preparation of Tetrahydrofuran Derivatives of High Optical Purity
Seemayer, Robert,Schneider, Manfred P.
, p. 2359 - 2360 (2007/10/02)
3,4-Disubstituted tetrahydrofurans (1)-(4) and (7) of high optical purities have been prepared by enantioselective enzyme hydrolysis of their acetates (+/-)-(1a) - (4a) and (7a) using a lipase from Pseudomonas sp. (SAM-II).
NOVEL (4+1) FRAGMENT COMBINATION APPROACH TO CHIRAL CYCLOPENTANOIDS FROM TARTARIC ACID
Barriere, Francoise,Barriere, Jean-Claude,Barton, Derek H. R.,Cleophax, Jeanine,Gateau-Olesker, Alice,et al.
, p. 3121 - 3124 (2007/10/02)
A chiral cyclopentanoid building block 29 has been synthesized in a "one pot" cyclization process from epoxides 22-25 (which are readily accessible from (R,R)-(+)-tartaric acid) with the carbanion derived from phenylthioacetonitrile (PhS-CH2-CN).
