183433-86-5

Upstream product

• 100-39-0 benzyl bromide 
• 183433-85-4 6-chloro-4-[1-hydroxypropyl]-2-methoxy-5-methylpyridine 
• 183433-84-3 6-chloro-2-methoxy-3-methyl-4-(1-oxopropyl)pyridine 
• 183433-83-2 6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxy-3-methylpyridine 
• 183433-64-9 6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine 

Downstream Products

• 183433-87-6 6-methoxy-5-methyl-4-[1-(phenylmethoxy)propyl]pyridine-2-carboxylic acid, propyl ester 
• 183433-91-2 (+/-) O-benzylmappicine 
• 183433-89-8 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione-2-carboxylic acid 1,1-dimethylethyl ester 
• 183433-88-7 1,6-dihydro-5-methyl-6-oxo-4-[1-(phenylmethoxy)propyl]-2-pyridinecarboxylic acid, propyl ester 
• 183433-90-1 2,3-dihydro-6-methyl-7-[1-(phenylmethoxy)-propyl]-1,5-indolizinedione 
• 55854-89-2 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one 

Relevant academic research and scientific papers

Synthesis of (+/-) mappicine and mappicine ketone

Mappicine and mappicine ketone are camptothecin analogs of interest as antiviral agents. A novel synthesis of these compounds is described using a Friedlander condensation. The requisite ketone is prepared via a regioselective ortho-directed metallation/a