183442-69-5

Upstream product

• 100-39-0 benzyl bromide 
• 339190-42-0 (E)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 120924-52-9 DL-α-Allyl-Phenylglycin-methylester 

Downstream Products

• 203518-05-2 C₄₃H₅₆N₈O₈S₂ 
• 203453-41-2 C₄₃H₅₄N₈O₈S₂ 
• 183442-78-6 C₃₇H₅₂ClN₇O₈S 

Relevant academic research and scientific papers

A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids

A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.

The 'unexpected' epimerization on bicyclic thiazolidine γ-lactam scaffolds

Preliminary findings related to the base induced cyclization and spontaneous epimerization leading to stereochemically defined bicyclic thiazolidine γ-lactam systems are reported.

The synthesis of β-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone

We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.

Secondary structure peptide mimetics: Design, synthesis, and evaluation of β-strand mimetic thrombin inhibitors

Constrained dipeptide mimetic templates were designed to mimic the secondary structure of peptides in a β-strand conformation. Two templates corresponding to the D-Phe-Pro portion of the thrombin inhibitor D-Phe-Pro- ArgCH2Cl were synthesized a