1835-57-0Relevant articles and documents
Nitrogen Arylation for Macrocyclization of Unprotected Peptides
Lautrette, Guillaume,Touti, Fay?al,Lee, Hong Geun,Dai, Peng,Pentelute, Bradley L.
supporting information, p. 8340 - 8343 (2016/07/26)
We describe an efficient and mild method for the synthesis of macrocyclic peptides via nitrogen arylation from unprotected precursors. Various electrophiles and lysine-based nucleophiles were investigated and showed high-yielding product formation, even f