1835-57-0Relevant academic research and scientific papers
Nitrogen Arylation for Macrocyclization of Unprotected Peptides
Lautrette, Guillaume,Touti, Fay?al,Lee, Hong Geun,Dai, Peng,Pentelute, Bradley L.
supporting information, p. 8340 - 8343 (2016/07/26)
We describe an efficient and mild method for the synthesis of macrocyclic peptides via nitrogen arylation from unprotected precursors. Various electrophiles and lysine-based nucleophiles were investigated and showed high-yielding product formation, even f
Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides
Zou, Yekui,Spokoyny, Alexander M.,Zhang, Chi,Simon, Mark D.,Yu, Hongtao,Lin, Yu-Shan,Pentelute, Bradley L.
supporting information, p. 566 - 573 (2014/01/06)
Here we describe a general synthetic platform for side-chain macrocyclization of an unprotected peptide library based on the SNAr reaction between cysteine thiolates and a new generation of highly reactive perfluoroaromatic small molecule linke
