183500-72-3Relevant academic research and scientific papers
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
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Page column, (2010/01/21)
The present invention comprises piperazine/piperazinone-containing compounds having multicyclic ring system substituents on one of the piperazine/piperazinone nitrogens, which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Dinsmore, Christopher J.,Williams, Theresa M.,O'Neill, Timothy J.,Liu, Dongming,Rands, Elaine,Culberson, J. Christopher,Lobell, Robert B.,Koblan, Kenneth S.,Kohl, Nancy E.,Gibbs, Jackson B.,Oliff, Allen I.,Graham, Samuel L.,Hartman, George D.
, p. 3301 - 3306 (2007/10/03)
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
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, (2008/06/13)
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
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, (2008/06/13)
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras
