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(17R,5Z,8Z,11Z,14Z)-17-Hydroxy-5,8,11,14-eicosatetraenoic acid, commonly referred to as 17-HETE, is a hydroxyeicosatetraenoic acid, a class of eicosanoids derived from the metabolism of arachidonic acid by the enzyme lipoxygenase. This bioactive lipid mediator plays a pivotal role in a variety of physiological processes, including inflammation, immune response, and blood pressure regulation. Additionally, 17-HETE has been the subject of research for its potential implications in cancer and other diseases, making it a significant molecule in the body's response to injury and disease.

183509-24-2

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183509-24-2 Usage

Uses

Used in Pharmaceutical Research:
17-HETE is utilized as a target for drug development in pharmaceutical research, given its involvement in inflammation and immune response. Its modulation can potentially lead to treatments for inflammatory conditions and immune-related disorders.
Used in Cardiovascular Research:
In cardiovascular research, 17-HETE is used as a biomarker and a therapeutic target for the regulation of blood pressure. Understanding its role in cardiovascular health can contribute to the development of treatments for hypertension and related conditions.
Used in Cancer Research:
17-HETE is employed as a subject of investigation in cancer research to explore its potential role in tumor biology. Its involvement in cell signaling and regulation makes it a candidate for targeted therapies in oncology.
Used in Diagnostics:
As a biomarker, 17-HETE levels can be measured in biological samples to assess an individual's health status, particularly in relation to inflammatory and immune responses, as well as cardiovascular and potentially oncological conditions.
Used in Nutritional Science:
Understanding the role of 17-HETE in physiological processes can inform nutritional science, potentially leading to dietary interventions that modulate its production or effects to promote health and prevent disease.
Each application of 17-HETE leverages its unique biochemical properties and involvement in critical biological pathways, underscoring its multifaceted importance in medicine and health sciences.

Check Digit Verification of cas no

The CAS Registry Mumber 183509-24-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,5,0 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183509-24:
(8*1)+(7*8)+(6*3)+(5*5)+(4*0)+(3*9)+(2*2)+(1*4)=142
142 % 10 = 2
So 183509-24-2 is a valid CAS Registry Number.

183509-24-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (17R)-17-hydroxyicosa-5,8,11,14-tetraenoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:183509-24-2 SDS

183509-24-2Downstream Products

183509-24-2Relevant academic research and scientific papers

A convergent synthesis of (17R,5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid analogues and their tritiated derivatives

Ivanov, Igor V.,Romanov, Stepan G.,Shevchenko, Valery P.,Rozhkova, Elena A.,Maslov, Mikhail A.,Groza, Nataliya V.,Myasoedov, Nikolai F.,Kuhn, Hartmut,Myagkova, Galina I.

, p. 8091 - 8097 (2007/10/03)

17(R)-OH-AA and 14,15-dehydro-17(R)-OH-AA were synthesized from a common tetraacetylenic precursor and their azide derivatives were obtained in moderate yields via the corresponding p-toluenesulfonates. Since the azido group remained stable during tritiat

A simple preparation of 17(R)-hydroxyeicosatetraenoic and eicosapentaenoic acids from the eicosanoylphloroglucinols, components of the brown alga, Zonaria diesingiana

Munakata, Tatsuo,Ooi, Takashi,Kusumi, Takenori

, p. 249 - 250 (2007/10/03)

The alkaline treatment of 17(R)-hydroxyeicosatetraenoylphloroglucinol and eicosapentaenoylphloroglucinol, which are the major components of the methanol extract of the brown alga, Zonaria diesingiana (Dictyota) afforded 17(R)-hydroxyeicosatetraenoic and eicosapentaenoic acids, respectively, in good yields. The conformation of methyl ester of the 17(R)-hydroxy acid in a solution was studied by using 2NMA, a chiral anisotropic reagent.

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