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18355-96-9

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18355-96-9 Usage

Uses

Different sources of media describe the Uses of 18355-96-9 differently. You can refer to the following data:
1. (3-(Dimethylamino)propyl)triphenyl-phosphonium Bromide is used in preparation of olopatadine hydrochloride.
2. Reactant for preparation of:Topoisomerase I-targeting antitumor agentsC15-C21 stereopentad of discodermolide via cleavage of aminoglycosides, double-bond isomerization, and selective hydroxyl group protectionDiphenyl amine based sodium channel blockers, effective against hNav1.2Reactant for Wittig reaction with benzaldehyde

Check Digit Verification of cas no

The CAS Registry Mumber 18355-96-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,5 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18355-96:
(7*1)+(6*8)+(5*3)+(4*5)+(3*5)+(2*9)+(1*6)=129
129 % 10 = 9
So 18355-96-9 is a valid CAS Registry Number.
InChI:InChI=1/C23H27NP.BrH/c1-24(2)19-12-20-25(21-13-6-3-7-14-21,22-15-8-4-9-16-22)23-17-10-5-11-18-23;/h3-11,13-18H,12,19-20H2,1-2H3;1H/q+1;/p-1

18355-96-9 Well-known Company Product Price

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  • Aldrich

  • (305855)  (3-(Dimethylamino)propyl)triphenylphosphoniumbromide  98%

  • 18355-96-9

  • 305855-5G

  • 1,958.58CNY

  • Detail

18355-96-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-((Dimethylamino)propyl)triphenylphosphonium bromide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18355-96-9 SDS

18355-96-9Relevant articles and documents

Process improvement in the production of a pharmaceutical intermediate using a reaction calorimeter for studies on the reaction kinetics of amination of a bromopropyl compound

Sano, Takahiro,Sugaya, Toru,Kasai, Masaji

, p. 169 - 174 (1998)

A synthetic process to produce a pharmaceutical intermediate, [3-(dimethylamino)propyl]triphenylphosphonium bromide (1), was established in the laboratory. Process safety evaluations did not show any severe problems. In order to scale up to plant scale, w

Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof

-

Page/Page column 24, (2008/06/13)

The present invention provides a novel polymorphic form of olopatadine hydrochloride ([(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride), a selective histamine H1-receptor antagonist that is used for the treatment of ocular symptoms of seasonal allergic conjunctivitis. The present invention also provides novel methods for producing olopatadine on a large scale, and in a manner that is cost effective, provides a low level of impurities and eliminates the need to use the costly and dangerous base, butyllithium, which is used in prior art reactions for making olopatadine. The present invention further provides novel processes for carrying out a large scale production of 3-dimethylaminopropyltriphenylphosphonium bromide and its corresponding hydrobromide salt, which are employed in the production of olopatadine, and pharmaceutically acceptable salts of olopatadine.

Therapeutic agents

-

, (2008/06/13)

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which R1, R2 and R3 independently represent hydrogen, hydroxy, halo, alkyl or alkoxy; ALK1 represents a C2-6 alkylene chain optionally substituted by one or more C1-2 alkyl groups; Y represents a piperidine ring which is attached through nitrogen to ALK1 ; R4 represents hydrogen or a C1-4 alkyl group; the broken line in --- represents a bond, or is absent and the free valency on Y is taken up by hydrogen and the free valency on CR4 is taken up by hydrogen or a C1-4 alkyl group; ALK2 is absent or represents a C1-4 alkylene chain optionally substituted by one or more C1-2 alkyl groups; and R5 and R6 independently represent hydrogen, alkyl, phenyl, alkyl (optionally substituted) or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring (with a proviso); are disclosed which are antiinflammatory, antiallergic and immunomodulatory agents. Compositions containing these compounds and processes to prepare these compounds are also disclosed.

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