18359-64-3

Basic information

• Product Name: 1H-Indole, 5-bromo-2,3-dihydro-1-(phenylmethyl)-
• CAS NO: 18359-64-3
• Molecular Formula: C15H14BrN
• Molecular Weight: 288.187
• Mol File: 18359-64-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 5-bromo-2,3-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 5-bromo-2,3-dihydro-1-(phenylmethyl)-(18359-64-3)
• EPA Substance Registry System: 1H-Indole, 5-bromo-2,3-dihydro-1-(phenylmethyl)-(18359-64-3)

Safety Data

• Hazardous Substances Data: 18359-64-3(Hazardous Substances Data)

Upstream product

• 22190-33-6 5-bromoindoline 
• 100-39-0 benzyl bromide 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 10075-51-1 1-benzyl-5-bromo-1H-indole 

Relevant articles and documents

Frustrated Lewis Pair Catalyzed Dehydrogenative Oxidation of Indolines and Other Heterocycles

An acceptorless dehydrogenation of heterocycles catalyzed by frustrated Lewis pairs (FLPs) was developed. Oxidation with concomitant liberation of molecular hydrogen proceeded in high to excellent yields for N-protected indolines as well as four other substrate classes. The mechanism of this unprecedented FLP-catalyzed reaction was investigated by mechanistic studies, characterization of reaction intermediates by NMR spectroscopy and X-ray crystal analysis, and by quantum-mechanical calculations. Hydrogen liberation from the ammonium hydridoborate intermediate is the rate-determining step of the oxidation. The addition of a weaker Lewis acid as a hydride shuttle increased the reaction rate by a factor of 2.28 through a second catalytic cycle.