183665-96-5Relevant academic research and scientific papers
Design and synthesis of conformationally-constrained MMP inhibitors
Natchus, Michael G.,Cheng, Menyan,Wahl, Christopher T.,Pikul, Stanislaw,Almstead, Neil G.,Bradley, Rimma S.,Taiwo, Yetunde O.,Mieling, Glen E.,Michelle Dunaway,Snider, Catherine E.,McIver, John M.,Barnett, Bobby L.,McPhail, Sara J.,Anastasio, Melanie B.,De, Biswanath
, p. 2077 - 2080 (2007/10/03)
A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.
