18368-14-4Relevant academic research and scientific papers
1-Alkylthio-3-aryloxypropan-2-ols: Synthesis and enantiomer separation by lipase-catalyzed transesterification
Wielechowska, Monika,Plenkiewicz, Jan
, p. 3203 - 3210 (2007/10/03)
The optically active (R)- and (S)-1-alkylthio-3-aryloxypropan-2-ols were prepared in the reaction of the appropriate arylglycidyl ethers and alkyl thiols followed by lipase-catalyzed transesterification. The effect of aryl and alkyl substituents, the enzyme preparation as well as the reaction conditions have been compared in terms of enantiomeric excess of the obtained acetate and the unreacted alcohol.
