18368-66-6

Basic information

• Product Name: 3-Methyl-2(1H)-Pyridinethione
• Synonyms: 3-Methyl-2(1H)-Pyridinethione;2(1H)-Pyridinethione,3-methyl-(8CI,9CI);2(1H)-Pyridinethione, 3-methyl-;3-Methylpyridine-2(1H)-thione;3-Methyl-2-pyridinethiol;3-Methyl-1H-pyridine-2-thione
• CAS NO: 18368-66-6
• Molecular Formula: C₆H₇NS
• Molecular Weight: 125.19148
• Product Categories: PYRIDINE
• Mol File: 18368-66-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 163-165 °C
• Boiling Point: 191.881 °C at 760 mmHg
• Flash Point: 64.172 °C
• Appearance: /
• Density: 1.11 g/cm³
• Refractive Index: 1.586
• PKA: 9.79±0.40(Predicted)
• CAS DataBase Reference: 3-Methyl-2(1H)-Pyridinethione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-2(1H)-Pyridinethione(18368-66-6)
• EPA Substance Registry System: 3-Methyl-2(1H)-Pyridinethione(18368-66-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 18368-66-6(Hazardous Substances Data)

Usage

General Description

3-Methyl-2(1H)-pyridinethione, also known as 3-methyl-2-thiopyridine, is a heterocyclic compound with the molecular formula C6H7NS. It is a sulfur-containing derivative of pyridine and is commonly used in the pharmaceutical and agricultural industries for its antimicrobial and antifungal properties. It is often used as an active ingredient in dandruff shampoos due to its ability to combat fungal infections on the scalp. Additionally, 3-methyl-2(1H)-pyridinethione has potential applications in the synthesis of organic compounds and as a reagent in chemical reactions. It is a yellow solid at room temperature with a distinct odor and should be handled and stored according to proper safety regulations.

InChI:InChI=1/C6H7NS/c1-5-3-2-4-7-6(5)8/h2-5H,1H3

Upstream product

• 1003-56-1 3-methylpyridin-2-ol 
• 3430-17-9 2-bromo-3-picoline 
• 741232-06-4 4-amino-2-chlorophenyl 3-methylpyrid-2-yl sulphide 
• 18368-76-8 2 chloro-3-methylpyridine 
• 1003-68-5 5-methyl-pyridin-2-ol 
• 1003-73-2 3-picoline-N-oxide 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 1003-56-1 3-Methyl-1H-pyridin-2-one 

Downstream Products

• 741232-06-4 4-amino-2-chlorophenyl 3-methylpyrid-2-yl sulphide 
• 179687-72-0 2-chloro-4-nitrophenyl 3-methylpyrid-2-yl sulphide 
• 10273-90-2 2-phenyl-3-methylpyridine 
• 2249891-90-3 2-(allylsulfonyl)-3-methylpyridine 
• 64291-96-9 3-methyl-2-(4-methylphenyl)pyridine 
• 223480-78-2 3-methylpyridine-2-sulfonic acid 

Relevant articles and documents

Synthesis of Dipyridyl Sulfides from Pyridyl-Pyridinium Halides

Reactions of pyridyl-pyridinium halides with thiolpyridines and thiourea were investigated.New dipyridyl sulfides were obtained by this method. - Keywords: Di-(4-pyridyl)-sulfides; Pyridyl-pyridinium chlorides; Thiolpyridines; Thiourea

Grignard-Reagent-Promoted Desulfonylation/Intramolecular Coupling for the Synthesis of 2-(1-Fluorovinyl)pyridines

A novel process involving Grignard-reagent-promoted desulfonylation/intramolecular coupling of readily available α-fluoro-α,β-unsaturated-(2-pyridyl)sulfones was realized that provided a series of polysubstituted 2-(1-fluorovinyl)pyridines in good yields. The intrinsic coordination between pyridine and Mg(II) along with the "negative fluorine effect"of the substrates should play the key role for the smooth transformation in the absence of transition-metal catalysts.

PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS

Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein