1003-56-1

Basic information

• Product Name: 3-Methyl-2-pyridone
• Synonyms: 2(1H)-Pyridinone, 3-methyl-;2(1H)-Pyridone, 3-methyl-;3-Methyl-2-pyridinol;AKOS BBS-00002968;3-METHYL-2-PYRIDINONE;3-METHYL-2-PYRIDONE;3-METHYL-1,2-DIHYDROPYRIDIN-2-ONE;2-HYDROXY-3-METHYLPYRIDINE
• CAS NO: 1003-56-1
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• EINECS: 213-710-2
• Product Categories: C6;Heterocyclic Building Blocks;Pyridines
• Mol File: 1003-56-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 204.59°C (rough estimate)
• Flash Point: 172.7 °C
• Appearance: Light yellow needles
• Density: 1.1143 (rough estimate)
• Vapor Pressure: 0.000724mmHg at 25°C
• Refractive Index: 1.5444 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 12.61±0.10(Predicted)
• BRN: 1422044
• CAS DataBase Reference: 3-Methyl-2-pyridone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-2-pyridone(1003-56-1)
• EPA Substance Registry System: 3-Methyl-2-pyridone(1003-56-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-41-37/38-22
• Safety Statements: 36/37/39-26-22-36
• WGK Germany: 3
• Hazardous Substances Data: 1003-56-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow needles

Uses

3-Methyl-2-pyridone, is used as a reactant with chloro-methoxy-methane to produce 1-methoxymethyl-3-methyl-1H-pyridin-2-one. This reaction will need reagent solvent CH2Cl2. The reaction time is 24 hours with ambient temperature

InChI:InChI=1/C6H7NO/c1-5-3-2-4-7-6(5)8/h2-4H,1H3,(H,7,8)

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 1006-97-9 3-methylpyridin-2-yl acetate 
• 7647-01-0 hydrogenchloride 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 108-99-6 3-Methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 83766-89-6 3-methyl-2-ethoxypyridine 
• 110-44-1 sorbic Acid 
• 541-41-3 chloroformic acid ethyl ester 
• 142-08-5 2-Pyridone 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 3430-17-9 2-bromo-3-picoline 
• 61759-56-6 N-<(1E,3E)-1,3-pentadienyl>-1-pyrrolidinecarboxamide 

Downstream Products

• 18368-76-8 2 chloro-3-methylpyridine 
• 857436-24-9 3-methyl-5-trityl-pyridin-2-ol 
• 856965-73-6 5-(biphenyl-4-yl-diphenyl-methyl)-3-methyl-pyridin-2-ol 
• 3430-17-9 2-bromo-3-picoline 
• 58498-61-6 5-chloro-3-methylpyridin-2-ol 
• 51933-79-0 3-methyl-2-phenoxypyridine 
• 104396-10-3 1-(3-Methyl-2-pyridinyl)piperazine 
• 755031-65-3 3-(3-methoxy-4-nitrophenyl)-8-[2-(3-methyl-2-oxopyridin-1(2H)-yl)ethyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one 
• 1003-68-5 5-methyl-pyridin-2-ol 
• 18368-66-6 2-thiol-3-methylpyridine 
• 59273-17-5 5-hydroxy-3-methyl-2-pyridone 
• 154447-02-6 3-methylpyridin-2-yl trifluoromethanesulfonate 
• 1093655-85-6 1-[2-(methoxy-methyl)-4-nitrophenyl]-3-methyl-pyridin-2(1H)-one 
• 1420998-62-4 2-(3-methyl-2-oxo-2H-pyridin-1-yl)-4-oxazol-5-yl-benzonitrile 

Relevant articles and documents

-

-

Methyl ketone derivative, and preparation method and applications thereof

The invention discloses a methyl ketone derivative, and a preparation method and applications thereof. The preparation method comprises following steps: a ketone derivative and an organic peroxide are dissolved in a solvent, and reaction is carried out at 80 to 130 DEG C so as to obtain methyl pyrimidone and a methyl pyrimidone derivative. According to the preparation method, the ketone derivative is taken as a starting material; the raw materials are easily and widely available; products of different kinds can be obtained via the preparation method, and can be used directly or used in other further reaction. No metal is involved, so that the preparation method is suitable to be applied in pharmaceutical preparation technology. The preparation method is short in route, mild in reaction conditions, simple in reaction operation and postprocessing process, and high in yield, and is suitable for large-scale production.

(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.