18378-20-6

Basic information

• Product Name: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole
• Synonyms: BBD;BENZYLAMINO-4-NITROBENZ-2-OXA-1,3-DIAZOLE;4-BENZYLAMINO-7-NITROBENZ-2-OXA-1,3-DIAZOLE;7-BENZYLAMINO-4-NITROBENZ-2-OXA-1,3-DIAZOLE;4-Benzylamino-7-nitro-2,1,3-benzoxadiazole;Benzylamino-NBD ;7-nitro-N-(benzyl)benzofurazan-4-amine;4-BENZYLAMINO-7-NITROBENZOFURAZAN, FOR FLUORESCENCE*
• CAS NO: 18378-20-6
• Molecular Formula: C₁₃H₁₀N₄O₃
• Molecular Weight: 270.24
• EINECS: 242-261-5
• Product Categories: marker
• Mol File: 18378-20-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 206-209 °C
• Boiling Point: 413.36°C (rough estimate)
• Flash Point: 236.9 °C
• Appearance: Brown fine powder
• Density: 1.2858 (rough estimate)
• Vapor Pressure: 6.2E-09mmHg at 25°C
• Refractive Index: 1.6120 (estimate)
• Storage Temp.: Store at 2-8
• PKA: -3.78±0.45(Predicted)
• CAS DataBase Reference: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole(18378-20-6)
• EPA Substance Registry System: 7-Benzylamino-4-nitrobenz-2-oxa-1,3-diazole(18378-20-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• Hazardous Substances Data: 18378-20-6(Hazardous Substances Data)

Usage

Chemical Properties

BROWN FINE POWDER

InChI:InChI=1/C13H10N4O3/c18-17(19)11-7-6-10(12-13(11)16-20-15-12)14-8-9-4-2-1-3-5-9/h1-7,14H,8H2

Upstream product

• 7116-16-7 4-chloro-2,1,3-benzoxadiazole 
• 19155-86-3 5-chlorobenzo[c][1,2,5]oxadiazole 
• 1194-66-7 2,6-dichloronitrosobenzene 
• 1635-61-6 5-chloro-2-nitroaniline 
• 17348-69-5 5-chlorobenzofurazan-1-oxide 
• 5714-17-0 5-chloro-4-nitrobenzo[c]-[1,2,5]oxadiazole 
• 100-46-9 benzylamine 
• 10199-89-0 NBD chloride 

Relevant articles and documents

POTENT ANALOGUES OF THE C-MYC INHIBITOR 10074-G5 WITH IMPROVED CELL PERMEABILITY

The present invention relates compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell. The compounds exhibit increased inhibitory activity against c-Myc relative to the known c-Myc inhibitor small-molecule benzofurazan N-([1,1′-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine (10074-G5).

Derivatization of Amines with 4-Substituted 7-Nitrobenzofurazans

Electrophilic derivatives of 4-nitro-benzofurazan with different reactivities were used to synthesize 28 new mono- and disubstituted 4-amino-7-nitrobenzofurazans 2b, 2d, 2f-2i, 2l, 2m-2n, 3b-3f, 3h-3j, 4c-4d, 4f-4k, 4m, 4o-4p.A reaction mechanism is proposed on the basis of the differences of the reactivities and a preliminary kinetic examination.The acid character of the N-H-function in monosubstituted compounds is demonstrated by means of spectroscopical investigation of pKa-values.Data from i.r., u.v./vis, and fluorescence studies are offered.