18381-93-6Relevant academic research and scientific papers
GLUCOSE METABOLISM MODULATING COMPOUNDS
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, (2016/11/14)
The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyperglycemia.
HYPOGLYCEMIC DIHYDROPYRIDONES
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Page/Page column 54, (2010/04/03)
The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods o
Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists
Xie, Yuli,Raffo, Anthony,Ichise, Masanori,Deng, Shixian,Harris, Paul E.,Landry, Donald W.
scheme or table, p. 5111 - 5114 (2009/07/18)
Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone
Reaction of Ethyl χ-Bromo-β-methoxycrotonate with Carbonyl Compounds. Synthesis of 4-methoxy-6-substituted-5,6-dihydro-2H-pyran-2-ones and 3-Substituted 3-Pyrazolin-5-ones
Shandala, Mowafak Y.,Ayoub, Mikdad T.,Mohammad, Mouyayed J.
, p. 1755 - 1756 (2007/10/02)
Ethyl β-methoxycrotonate I reacts with substituted carbonyl compounds II in benzene to give 4-methoxy-6-substituted-5,6-dihydro-2H-pyran-2-ones III.The reaction of IIIa and j with hydrazine hydrate in ethanol leads to 3--5-hy
