3510-99-4

Usage

InChI:InChI=1/C7H12O3/c1-4-10-7(8)5-6(2)9-3/h5H,4H2,1-3H3/b6-5+

Upstream product

• 141-97-9 ethyl acetoacetate 
• 124-41-4 sodium methylate 
• 141-78-6 ethyl acetate 
• 149-73-5 trimethyl orthoformate 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 67-56-1 methanol 

Downstream Products

• 144-62-7 oxalic acid 
• 1116-51-4 ethyl χ-bromo-β-methoxycrotonate 
• 96570-08-0 6-Benzoyl-3-methoxy-5-phenyl-cyclohex-2-enone 
• 96570-12-6 6-Benzoyl-3-methoxy-5-(4-methoxy-phenyl)-cyclohex-2-enone 
• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 1436855-48-9 ethyl 4-hydroxy-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 
• 3160-40-5 4-(4-chlorophenyl)-3-buten-2-one 
• 111671-02-4 Acetic acid [2-(acetoxy-phenyl-methyl)-3-methoxy-5-oxo-2,5-dihydro-furan-2-yl]-phenyl-methyl ester 
• 78376-33-7 Acetic acid [2-(hydroxy-phenyl-methyl)-3-methoxy-5-oxo-2,5-dihydro-furan-2-yl]-phenyl-methyl ester 
• 78376-14-4 5-[Hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-4-methoxy-5H-furan-2-one 
• 108932-51-0 methyl 5-(cis-2',3'-epoxy-1',1'-dimethoxy-3'-phenylpropyl)tetronate 
• 108932-51-0 5-[Dimethoxy-((2R,3S)-3-phenyl-oxiranyl)-methyl]-4-methoxy-5H-furan-2-one 
• 40072-82-0 4-Methoxy-5-[1-methoxy-1-((2S,3R)-3-phenyl-oxiranyl)-meth-(E)-ylidene]-5H-furan-2-one 
• 40072-82-0 4-Methoxy-5-[1-methoxy-1-((2S,3R)-3-phenyl-oxiranyl)-meth-(Z)-ylidene]-5H-furan-2-one 

Relevant academic research and scientific papers

Synthesizing method of 2-amino-4-hydroxyl-6-methylpyrimidine

The invention relates to a synthesizing method of 2-amino-4-hydroxyl-6-methylpyrimidine. The synthesizing method comprises the following steps of (a) synthesizing of 2-methoxyl-2-ethyl butyrate: mixing ethyl acetate and a catalyst, after heating and refluxing, performing self-condensation reaction of the ethyl acetate, so as to obtain the 2-methoxyl-2-ethyl butyrate; (b) synthesizing of 2-amino-4-hydroxyl-6-methylpyrimidine; dissolving the 2-methoxyl-2-ethyl butyrate into methyl alcohol, dissolving, mixing with guanidine hydrochloride, after heating and refluxing, evaporating the residual solvent, adding deionized water until completely dissolving, using diluted hydrochloric acid to adjust the pH (potential of hydrogen) value, separating solid and filtering, spraying the solid by deionized water, obtaining the 2-amino-4-hydroxyl-6-methylpyrimidine, and drying. The synthesizing method has the advantages that the toxicity of the raw material is low, the cost is low, and the green and environment-friendly effects are realized; the traditional synthesizing method using volatile acetone with stronger toxicity or phenylboronic acid with hypertoxicity is improved, the injury to production personnels and environments is decreased, and the difficulty in production is reduced.

NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVES AND METHOD FOR PREPARING THE SAME

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVE AND A PRODUCTION METHOD FOR SAME

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

Synthetic Routs to the Piperolides, Faydenolides, Epoxypiperolides, and Related Compounds

Syntheses of the piperolides, the faydenolides, epoxypiperolide, and related compounds are described. (+/-)-Narthogenin is also efficiently produced.

Reaction of Ethyl β-Methoxycrotonate with some α,β-Unsaturated Carbonyl Compounds. Synthesis of 6-Aroyl-5-aryl-3-methoxycyclohex-2-enones

3-Aryl-1-phenyl-2-propen-1-ones Ia-h and 1-aryl-3-phenyl-2-propen-1-ones Ii-l reacted with ethyl β-methoxycrotonate (II) in the presence of sodium hydride in dry THF at 0 deg C for 10 hours to give the corresponding 6-aroyl-5-aryl-3-methoxy-2-cyclohexen-1-ones III.The structures of the products were confirmed by ir, pmr, (13)C nmr and uv spectroscopy.