183812-77-3

Upstream product

• 183553-81-3 N-[2R-hydroxy-3-[[(1,3-benzodioxol-5-yl) sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-2S-[(chloroacetyl)amino]-3,3-dimethylbutanamide 
• 765-30-0 Cyclopropylamine 
• 565227-89-6 tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate 
• 565227-88-5 tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate 

Downstream Products

• 565227-88-5 tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate 
• 565227-89-6 tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate 
• 565227-90-9 tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxy-2-[3H]-propyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate 
• 183556-72-1 2S-[[(N-cyclopropylamino)acetyl]amino]-N-[2R-hydroxy-3-[[(1,3-benzodioxol-5-yl)sulfonyl](2-methylpropyl)amino]-1S-(phenylmethyl)propyl]-3,3-dimethylbutanamide hydrochloride 

Relevant academic research and scientific papers

Preparation of labeled bis-amino acid hydroxyethylamino sulfonamide HIV protease inhibitors

Preparation of radiolabeled sulfonamide HIV protease inhibitors, DMP852 and DMP853 is described. The C-14 labeling of DMP852 was accomplished by acylation of the intermediate amine with [1-14C]-chloroacetic anhydride followed by the treatment of the chloroacetyl derivative with methylamine. Due to the rapid loss of the methylglycine moiety during metabolism studies, a route that involved an oxidation-reduction sequence was employed to prepare tritium labeled DMP852. Similar methodology was utilized to prepare tritium labeled DMP853. Copyright

Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.