183814-30-4 Usage
Description
(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate, also known as Formoterol Fumarate Dihydrate, is a selective β2-adrenergic receptor agonist. It is a pale yellow solid with chemical properties that make it a promising pharmaceutical candidate for respiratory applications.
Uses
Used in Pharmaceutical Industry:
Formoterol Fumarate Dihydrate is used as a selective β2-adrenergic receptor agonist for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles in the airways and increase air flow to the lungs, providing relief from shortness of breath and other respiratory symptoms.
Used in Respiratory Applications:
Formoterol Fumarate Dihydrate is used as an antiasthmatic agent to manage and prevent asthma attacks. Its selective action on β2-adrenergic receptors helps to reduce inflammation and constriction in the airways, improving lung function and overall respiratory health.
Biological Activity
Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.
Biochem/physiol Actions
β2-Adrenoreceptor agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 183814-30-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,8,1 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 183814-30:
(8*1)+(7*8)+(6*3)+(5*8)+(4*1)+(3*4)+(2*3)+(1*0)=144
144 % 10 = 4
So 183814-30-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H24N2O4.C4H4O4.2H2O/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;2-1+;;/t13-,19+;;;/m1.../s1
183814-30-4Relevant articles and documents
Preparation method and application of formoterol and medicinal salt thereof
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Paragraph 0098-0100, (2021/03/31)
The invention provides a preparation method and application of formoterol and medicinal salt thereof, and relates to the technical field of chemical synthesis. The preparation method of formoterol comprises the following steps: reacting a compound shown as a formula I under the action of a palladium-containing catalyst, a hydrogen donor and an alkali reagent to obtain a compound shown as a formulaII, wherein the hydrogen donor is a combination of formic acid and ammonium formate. The compound shown in the formula I contains O-benzyl, N-benzyl, formyl and methoxyl at the same time, hydrogen can be slowly and continuously generated under the action of a palladium-containing catalyst by adopting the combination of a hydrogen donor and an alkali reagent, a method for directly introducing hydrogen in the conventional technology is replaced, benzyl of O-benzyl and N-benzyl on the compound shown in the formula I can be removed, formyl and methoxyl are not affected, the yield and purity of the product are guaranteed, reaction conditions are mild, technological operation is safe and easy to control, and the method is simple, convenient and easy to implement and suitable for large-scale production.
Novel aerosol formulation containing a polar fluorinated molecule
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, (2008/06/13)
The present invention relates to a stable pharmaceutical aerosol formulation intended for inhalation. The formulation contains an active substance, an aerosol propellant, a polar flurorinated molecule and an excipient. The preferred propellant is HFA 134a or HFA 227 or a mixture thereof.