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Product FOB Price Min.Order Supply Ability Supplier
Fumaric Acid
Cas No: 110-17-8
USD $ 1800.0-1900.0 / Metric Ton 1 Metric Ton 30 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
Bulk Trans-Butenedioic acid Powder Fumaric acid
Cas No: 110-17-8
USD $ 20.0-20.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
Fumaric acid
Cas No: 110-17-8
USD $ 1500.0-1570.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Week Arshine Pharmaceutical Co., Limited Contact Supplier
Fumaric acid
Cas No: 110-17-8
No Data 1000 Kilogram 100000 Metric Ton/Year SJZ THLD IMP & EXP CO LTD Contact Supplier
FUMARIC ACID
Cas No: 110-17-8
No Data 1 Kilogram 10000 Metric Ton/Day Ningbo Qicheng Chemical Co.,Ltd. Contact Supplier
High quality Fumaric Acid supplier in China
Cas No: 110-17-8
No Data No Data 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Fumaric acid
Cas No: 110-17-8
USD $ 15.0-15.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
High purity of Fumaric Acid /pharmaceutical intermediate
Cas No: 110-17-8
USD $ 3.0-3.0 / Gram 1 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Best Quality Fumaric acid TNJ
Cas No: 110-17-8
No Data 100 Kilogram 2000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Fumaric acid
Cas No: 110-17-8
No Data 1 Gram 100 Metric Ton/Day Hangzhou Dingyan Chem Co., Ltd Contact Supplier

110-17-8 Usage

Uses

1. Fumaric acid is used for the production of unsaturated polyester resin. This kind of resin is characterized by excellent resistance to chemical corrosion as well as heat resistance; the copolymer of fumaric acid and vinyl acetate is a kind of excellent adhesive. Its copolymer with styrene copolymer is the raw material for the manufacture of glass fiber. The plasticizer of the fumaric acid is non-toxic and can be applied to the vinyl acetate latex contact with food. This product is the intermediate of pharmaceutical and optical bleaching agents and other fine chemicals. Neutralization of fumaric acid with sodium carbonate can generate sodium fumarate ([17013-01-3]), and then replaced with ferrous sulfate to get iron fumarate, being the drug Fersamal used for the treatment of small red blood cell anemic. The product, as a food additive-sourness agent, used in soft drinks, fruit sugar, jelly, ice cream with most of them used in combination with sourness agent, citric acid. The monosidum salt made from the reaction between fumaric acid and sodium hydroxide can also used as sour seasoning, also used as the intermediate of synthetic resin and mordant.
2. Fumaric acid is included in many dairy-based products. These include dairy drinks such as chocolate milk, cocoa, eggnog, condensed milk and whey protein beverages. It also may be added to clotted cream, milk and cream powders and milk and cream analogues (substitutes). Fumaric acid is added to cheese products, including processed cheese and cheese substitutes. Dairy-based desserts, such as pudding, flavored yogurt, sherbet and sorbet may include fumaric acid as well. Dairy fat spreads and blended spreads can include fumaric acid, and so can preserved eggs and egg-based desserts such as custard.
3. Some processed and packaged foods have fumaric acid added to them to help stabilize them and enhance their flavor. For example, many processed meats, such as bacon and canned meats, have added fumaric acid. Frozen seafood, smoked meats and the edible casings around sausages might also have fumaric acid added to them. Fermented, canned, dried and processed fruits and vegetables can contain the food additive as well. Rice cakes and other precooked rice foods, dried or preserved eggs, mustard, vinegar, cider, wine and other alcoholic beverages are additional examples of foods that might contain fumaric acid.

Purification Methods

Crystallise it from hot M HCl or water and dry it at 100o. [Beilstein 2 IV 2202.]

General Description

A colorless crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Combustible, though may be difficult to ignite. Used to make paints and plastics, in food processing and preservation, and for other uses.

Reactivity Profile

Fumaric acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Fumaric acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Partial carbonization and formation of maleic anhydride occur at 446° F (open vessel).

Description

Fumaric acid is an important kind of organic chemical raw materials as well as the intermediate of fine chemical products. Meanwhile, it is also an important kind of derivatives of maleic anhydride, being widely used in food, coatings, resins and plasticizers. In the food industry, fumaric acid, used as souring agent, can be applied to soft drinks, western-style wine, cold drinks, fruit juice concentrate, canned fruit, pickles and ice cream. As an acidic substance used as solid beverage gas production agent, it has excellent bubble durability with delicate product organization.
Fumaric acid has been used as a food acidulant since 1946. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.
Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. As an additive, fumaric acid is produced synthetically, mainly from malic acid from apples. Fumaric acid as an additive is regulated under the Codex Alimentarius General Standard for Food Additives (GSFA), a collection of internationally recognized standards.The U.S. Food and Drug Administration considers it safe.

Uses

Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.

Air & Water Reactions

Slightly soluble in water.

Health Hazard

Inhalation of dust may cause respiratory irritation. Compound is non-toxic when ingested. Prolonged contact with eyes or skin may cause irritation.

Chemical Properties

Fumaric acid is naturally presented in Corydalis, mushrooms and fresh beef. Product precipitated from the water is monoclinic needle-like, prismatic or leaf-like white crystalline or crystalline powder. It is odorless with a special and strong sour, which is about 1.5 times that of the citric acid. It has a melting point 287 ° C, the boiling point of 290 ° C with subjecting to sublimation at temperature above 200 ° C. When being heated to 230 ° C, it will lose water and become maleic anhydride. Its co-boiling with water can produce DL-malic acid. It is soluble in ethanol, slightly soluble in water and ether, but insoluble in chloroform. The pH value of the 3% aqueous solution is 2.0 to 2.5 with a strong buffering performance, in order to maintain the pH of the aqueous solution at around 3.0. This product is non-toxic; rat-oral LD50: 8000mg/kg.

Definition

ChEBI: A butenedioic acid in which the C2C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
InChI:InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

110-17-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (03761)  Fumaricacid  tested according to USP/NF 110-17-8 03761-500G 2,300.22CNY Detail
Sigma-Aldrich (47910)  Fumaricacid  ≥99.0% (T) 110-17-8 47910-1KG 703.17CNY Detail
Sigma-Aldrich (47910)  Fumaricacid  ≥99.0% (T) 110-17-8 47910-100G 565.11CNY Detail
Sigma-Aldrich (47910)  Fumaricacid  ≥99.0% (T) 110-17-8 47910-25G 497.25CNY Detail
Sigma-Aldrich (47910)  Fumaricacid  ≥99.0% (T) 110-17-8 47910-5G 441.09CNY Detail
Vetec (V900245)  Fumaricacid  Vetec reagent grade, 99% 110-17-8 V900245-500G 98.28CNY Detail
USP (1286708)  Fumaricacid  United States Pharmacopeia (USP) Reference Standard 110-17-8 1286708-200MG 4,662.45CNY Detail
Sigma-Aldrich (F0600000)  Fumaricacid  European Pharmacopoeia (EP) Reference Standard 110-17-8 F0600000 1,880.19CNY Detail
Sigma-Aldrich (PHR1270)  Fumaric Acid  pharmaceutical secondary standard; traceable to USP, PhEur 110-17-8 PHR1270-1G 718.73CNY Detail
Sigma-Aldrich (76635)  Fumaricacid  certified reference material, TraceCERT® 110-17-8 76635-100MG 329.94CNY Detail
Alfa Aesar (A10976)  Fumaric acid, 99%    110-17-8 10000g 1729.0CNY Detail
Alfa Aesar (A10976)  Fumaric acid, 99%    110-17-8 2500g 438.0CNY Detail

110-17-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name fumaric acid

1.2 Other means of identification

Product number -
Other names U-1149

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Processing Aids and Additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110-17-8 SDS

110-17-8Synthetic route

maleic acid
110-16-7

maleic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With (E)-4-(2-chlorostyryl)pyridine In methanol at 20℃; for 720h;100%
With maleic anhydride In water at 190℃; for 6h; Reagent/catalyst; Inert atmosphere; Autoclave; Green chemistry;99.5%
With N-Bromosuccinimide; dibenzoyl peroxide; acetic acid for 6h; Heating;90%
C13H10ClN*C4H4O4*0.5C4H4O4

C13H10ClN*C4H4O4*0.5C4H4O4

A

1,3-bis(4-pyridyl)-2,4-bis(2-chlorophenyl)cyclobutane

1,3-bis(4-pyridyl)-2,4-bis(2-chlorophenyl)cyclobutane

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
UV-irradiation;A 100%
B n/a
meso-2,3-dibromosuccinic acid
608-36-6

meso-2,3-dibromosuccinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With aluminum oxide for 0.0166667h; microwave irradiation;98%
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 20℃; for 0.75h;89%
With sodium sulfide oder mit aehnlichen Thiosalzen;
(E)-But-2-enedioic acid bis-(1-phenoxy-ethyl) ester

(E)-But-2-enedioic acid bis-(1-phenoxy-ethyl) ester

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0℃; for 1h;98%
In dichloromethane at 0℃; for 1h; Product distribution; 5percent CF3COOH; other reagent;98%
(+-)-2,3-dibromosuccinic acid
1114-00-7

(+-)-2,3-dibromosuccinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With aluminum oxide for 0.0166667h; microwave irradiation;98%
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 20℃; for 1h;90%
malic acid
617-48-1

malic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
96%
In neat (no solvent) at 200℃; for 4h; Inert atmosphere;96.6%
at 180℃; for 4h; Temperature; Inert atmosphere;88%
C22H18O10

C22H18O10

A

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

B

4,6-dimethoxyanthracene-1,2-dicarboxylic anhydride

4,6-dimethoxyanthracene-1,2-dicarboxylic anhydride

Conditions
ConditionsYield
In diphenylether Heating;A n/a
B 94%
C21H16O9

C21H16O9

A

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

B

4-methoxyanthracene-1,2-dicarboxylic anhydride

4-methoxyanthracene-1,2-dicarboxylic anhydride

Conditions
ConditionsYield
In diphenylether Heating;A n/a
B 90%
trisodium tris(3-sulfophenyl)phosphine
63995-70-0

trisodium tris(3-sulfophenyl)phosphine

Acetylenedicarboxylic acid
142-45-0

Acetylenedicarboxylic acid

A

tris(natrium-m-sulfonatophenyl)phosphanoxid
98511-67-2

tris(natrium-m-sulfonatophenyl)phosphanoxid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In water for 5h; Ambient temperature;A n/a
B 87%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

4-hydroxybutanoic acid
591-81-1

4-hydroxybutanoic acid

E

malic acid
617-48-1

malic acid

F

succinic acid
110-15-6

succinic acid

G

terephthalic acid
100-21-0

terephthalic acid

H

acetic acid
64-19-7

acetic acid

I

propionic acid
802294-64-0

propionic acid

J

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd/0.2percent Re on Rutile TiO2 at 110℃; for 170 - 1009h; Product distribution / selectivity;A 0.86%
B 4.34%
C 0.28%
D 1.24%
E 0%
F 85.51%
G 0%
H 0.04%
I 0%
J 0%
C19H14O6

C19H14O6

A

2-anthroic acid
613-08-1

2-anthroic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In diphenylether Heating;A 84%
B n/a
maleic anhydride
108-31-6

maleic anhydride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With thiourea In water at 25 - 30℃;83.6%
With hydrogenchloride
With water; thiourea
Stage #1: maleic anhydride With water at 45 - 50℃; for 2.25h;
Stage #2: With thiourea at 45 - 50℃; for 1h;
290 g
carbon monoxide
201230-82-2

carbon monoxide

acetylene
74-86-2

acetylene

A

succinic acid
110-15-6

succinic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With 8-nitroquinoline; water; hydrogen bromide; lithium bromide; palladium(II) bromide In acetonitrile at 30℃; for 4.26667h; Reagent/catalyst; Temperature; Overall yield = 2.56 g;A 80.27%
B 17.12%
(R)-4,4,4-trichloro-3-hydroxybutanoic acid
80513-23-1

(R)-4,4,4-trichloro-3-hydroxybutanoic acid

A

D-Malic acid
636-61-3

D-Malic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 24h;A 79%
B n/a
(+/-)-9,10-ethanoanthracene-2,3,trans-11,12-tetracarboxylic acid

(+/-)-9,10-ethanoanthracene-2,3,trans-11,12-tetracarboxylic acid

A

2,3-anthracenedicarboxylic acid anhydride
6812-14-2

2,3-anthracenedicarboxylic acid anhydride

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
In diphenylether Heating;A 79%
B n/a
maleic anhydride
108-31-6

maleic anhydride

2-allyloxy-2-phenylethan-1-ol
75455-48-0

2-allyloxy-2-phenylethan-1-ol

A

mono(2-allyloxy-2-phenylethyl) fumarate

mono(2-allyloxy-2-phenylethyl) fumarate

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
Stage #1: maleic anhydride; 2-allyloxy-2-phenylethan-1-ol With 4-methoxy-phenol In toluene at 130℃; for 5h;
Stage #2: With hydrogenchloride In water; toluene at 130℃; for 10h;
A 75.1%
B n/a
(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hypochlorite; nickel dichloride In dichloromethane; water at 0 - 20℃; for 4h;75%
tartaric acid
87-69-4

tartaric acid

A

glycolic Acid
79-14-1

glycolic Acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h; Reagent/catalyst;A 27%
B 73%
maleic anhydride
108-31-6

maleic anhydride

A

malic acid
617-48-1

malic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With water at 190℃; for 1h; Temperature; Concentration; Time; Sealed tube; Green chemistry;A n/a
B 72%
(S)-Malic acid
97-67-6

(S)-Malic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 120℃;71%
With propan-1-ol Bei der Einw. von Bact. coli unter anaeroben Bedingungen;
bei der Einw. von Muskelextrakt oder Muskelbrei;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With copper; copper(II) perchlorate In methanol for 2h; Ambient temperature;71%
With sodium sulfide oder mit aehnlichen Thiosalzen;
With sodium thioethylate oder mit aehnlichen Thiosalzen;
d,l-dibromo succinic acid
526-78-3, 608-35-5, 608-36-6, 1114-00-7

d,l-dibromo succinic acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With copper; copper(II) perchlorate In methanol for 3.5h; Ambient temperature;70%
(S)-3,4-Epoxybutyric Acid
33278-09-0

(S)-3,4-Epoxybutyric Acid

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With sodium hypochlorite; nickel dichloride In dichloromethane; water at 0 - 20℃; for 4h;69%
tartaric acid
87-69-4

tartaric acid

A

glycolic Acid
79-14-1

glycolic Acid

B

LACTIC ACID
849585-22-4

LACTIC ACID

C

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h;A 69%
B 7%
C 24%
furfural
98-01-1

furfural

A

2-furanoic acid
88-14-2

2-furanoic acid

B

succinic acid
110-15-6

succinic acid

C

maleic acid
110-16-7

maleic acid

D

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With dihydrogen peroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; methyltrioxorhenium(VII) In water at 20℃;A 7%
B 12%
C 66%
D 13%
furfural
98-01-1

furfural

A

maleic acid
110-16-7

maleic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With dihydrogen peroxide; acidine In water at 100℃; for 0.5h; Temperature;A 61%
B 31%
With dihydrogen peroxide; acidine In water at 100℃; for 2h; Time;A 10%
B 48%
With sodium chlorate; vanadium pentoxide In water at 85 - 95℃; for 19h;A n/a
B 47%
With sodium chlorate; vanadia In water at 80 - 90℃; for 13h; Overall yield = 58 %; Overall yield = 42.3 g;A n/a
B n/a
With choline chloride; dihydrogen peroxide; oxalic acid In water at 50℃; for 24h; Reagent/catalyst; Green chemistry; Overall yield = 95.7 %Chromat.;
malic acid
617-48-1

malic acid

A

maleic acid
110-16-7

maleic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C

acrylic acid
79-10-7

acrylic acid

Conditions
ConditionsYield
sodium hydroxide In water at 340℃; under 129290 Torr; pH=3.17; Product distribution / selectivity;A 10.52%
B 6.88%
C 59.23%
toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

diethyl Fumarate
623-91-6

diethyl Fumarate

A

p-toluenesulfonamidosuccinic acid ethyl ester
104830-35-5

p-toluenesulfonamidosuccinic acid ethyl ester

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With potassium hydroxide In neat (no solvent) at 53℃; for 1h; Michael Addition; Sonication;A 50%
B n/a
malic acid
617-48-1

malic acid

A

succinic acid
110-15-6

succinic acid

B

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

Conditions
ConditionsYield
With hydrogen iodide; propionic acid at 160℃; under 25858.1 Torr; for 2h; Kinetics; Inert atmosphere;A 46%
B 10%
cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

norbornene-5,6-dicarboxylic acid
1200-88-0

norbornene-5,6-dicarboxylic acid

Conditions
ConditionsYield
In water; acetone at 50℃; for 24h; Diels-Alder Cycloaddition;100%
In 1,4-dioxane at 60℃; for 1h;94%
With N,N-dimethyl-formamide andere polare Loesungsmittel;
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole
172259-74-4

2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole

2-(3-aminopropyl)-8H-indeno[1,2-d]thiazole fumarate

2-(3-aminopropyl)-8H-indeno[1,2-d]thiazole fumarate

Conditions
ConditionsYield
Stage #1: 2-(3-phthalimidopropyl)-8H-indeno[1,2-d]thiazole With methylamine In methanol at 20℃; for 16h;
Stage #2: (2E)-but-2-enedioic acid In methanol
100%
(+)-N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide hydrochloride

(+)-N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide hydrochloride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide fumarate

N-(3-amino-propyl)-N-[(R)-1-(6-benzyl-3-chloro-2-methyl-7-oxo-6,7-dihydro-pyrazolo[1,5-c]pyrimidin-5-yl)-2-methyl-propyl]-4-methyl-benzamide fumarate

Conditions
ConditionsYield
In ethanol for 0.116667h; Heating / reflux;100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

dihydro-2(3H)furanone-[3,4,5,5-D4]

dihydro-2(3H)furanone-[3,4,5,5-D4]

Conditions
ConditionsYield
With deuterium; Ru4H4(CO)8(PBu3)4 In tetrahydrofuran at 180℃; for 48h;100%
(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane fumarate

(1R,5S)-3-methyl-6-(6-phenyl-pyridazin-3-yl)-3,6-diaza-bicyclo[3.2.0]heptane fumarate

Conditions
ConditionsYield
In methanol; ethyl acetate at 20℃; for 18h;100%
(1RS,3aRS)-1-[1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

(1RS,3aRS)-1-[1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C4H4O4*C25H29N3O

C4H4O4*C25H29N3O

Conditions
ConditionsYield
In ethanol100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol
207679-81-0

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

(R)-5-hydroxymethyl tolterodine fumarate salt
380636-50-0

(R)-5-hydroxymethyl tolterodine fumarate salt

Conditions
ConditionsYield
In acetone at 20℃; for 0.5h;100%
In acetone at 25 - 30℃; for 1h;2.4 g
3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane
855738-90-8

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane hemifumarate

3-[6-(1H-indol-3-yl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane hemifumarate

Conditions
ConditionsYield
In methanol; ethyl acetate at 20℃;100%
N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide
766558-09-2

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide difumarate

N-[2-[2-[4-[(3RS)-1-azabicyclo[2.2.2]oct-3-yl]-1-piperazinyl]-2-oxo-ethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzene-sulphonamide difumarate

Conditions
ConditionsYield
In methanol for 0.5h;100%
2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide
863613-79-0

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide fumarate

2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide fumarate

Conditions
ConditionsYield
In ethanol100%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

zinc diacetate
557-34-6

zinc diacetate

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

[Zn2(fumarate)2(4,4'-bipyridyl)]n

[Zn2(fumarate)2(4,4'-bipyridyl)]n

Conditions
ConditionsYield
100%
1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
1198187-79-9

1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-(1H-indol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine fumarate
1198187-81-3

1-(1H-indol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine fumarate

Conditions
ConditionsYield
Stage #1: 1-[1-(toluene-4-sulfonyl)-1H-indol-5-yl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine With sodium ethanolate In ethanol for 2h; Reflux;
Stage #2: (2E)-but-2-enedioic acid In ethanol
100%
(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole
1262011-69-7

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole fumarate
1262011-74-4

(2S,5R)-3-bromo-5-pyrrolidin-2-yl-4,5-dihydroisoxazole fumarate

Conditions
ConditionsYield
In methanol at 20℃; for 16h;100%
Bisegliptin

Bisegliptin

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile fumarate
1218908-87-2

(2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile fumarate

Conditions
ConditionsYield
In acetone at 45℃; for 0.5h; Product distribution / selectivity;100%
N-(3,4-Dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide
1212022-70-2

N-(3,4-Dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-(3,4-dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide fumarate

N-(3,4-dichloro-phenyl)-N-ethyl-3-piperidin-4-yl-propionamide fumarate

Conditions
ConditionsYield
In methanol; dichloromethane100%
meloxicam
71125-38-7

meloxicam

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C4H4O4*2C14H13N3O4S2

C4H4O4*2C14H13N3O4S2

Conditions
ConditionsYield
In tetrahydrofuran for 0.5h;100%
(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester
1236549-06-6

(1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate
173334-58-2

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxypropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-(2-propan-2-yl)nonanamide hemifumarate

Conditions
ConditionsYield
Stage #1: (1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester With palladium 10% on activated carbon; hydrogen In isopropyl alcohol at 20℃; under 760.051 Torr;
Stage #2: (2E)-but-2-enedioic acid In ethanol
100%
Stage #1: (1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester With palladium 10% on activated carbon In isopropyl alcohol at 20℃; under 760.051 Torr;
Stage #2: (2E)-but-2-enedioic acid In ethanol
85%
C7H13N3O2S
1579943-67-1

C7H13N3O2S

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

2-(4-methoxy-1,2,5-thiadiazol-3-yloxy)-N,N-dimethylethanamine fumarate
1580000-49-2

2-(4-methoxy-1,2,5-thiadiazol-3-yloxy)-N,N-dimethylethanamine fumarate

Conditions
ConditionsYield
In ethanol Inert atmosphere;100%
(R)-6-methylamino-2-methylheptene
1620401-56-0

(R)-6-methylamino-2-methylheptene

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(R)-isometheptene fumarate

(R)-isometheptene fumarate

Conditions
ConditionsYield
In ethanol at -20℃; Solvent; Temperature;100%
dispirocyclopropyldehydrocostus lactone
1403389-47-8

dispirocyclopropyldehydrocostus lactone

N,N-dimethylammonium chloride
506-59-2

N,N-dimethylammonium chloride

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

dispirocyclopropyldehydrocostus lactone

dispirocyclopropyldehydrocostus lactone

Conditions
ConditionsYield
Stage #1: dispirocyclopropyldehydrocostus lactone; N,N-dimethylammonium chloride With potassium carbonate In dichloromethane for 4h; Reflux;
Stage #2: (2E)-but-2-enedioic acid In methanol for 0.5h;
100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(methoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(ethoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone, fumarate salt

1-[5-(ethoxymethyl)-2-(2-hydroxy-3-(isopropylamino)propoxy)-phenyl]ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[2-hydroxy-3-(isopropylamino)propoxy]-5-(propoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(isopropoxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone, fumarate salt

1-{5-(butoxymethyl)-2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%
1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone, fumarate salt

1-{2-[3-(tert-butylamino)-2-hydroxypropoxy]-5-(pentyloxymethyl)phenyl}ethanone, fumarate salt

Conditions
ConditionsYield
In diethyl ether100%

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