18385-68-7 Usage
Uses
Used in Organic Synthesis:
2,3-Dihydro-5-methyl-4H-1-benzopyran-4-one is used as a reagent in cyclization and ring enlargement reactions of (arylazo)(isocyanato)benzopyran derivatives. This application is particularly relevant for the synthesis of novel tricyclic O,N-heterocycles, which are important structural motifs in various biologically active compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
The ability of 2,3-Dihydro-5-methyl-4H-1-benzopyran-4-one to participate in cyclization and ring enlargement reactions makes it a valuable intermediate in the development of new pharmaceutical agents. The resulting tricyclic O,N-heterocycles can be further modified and optimized for specific therapeutic applications, such as the treatment of various diseases and disorders.
Used in Chemical Research:
As a compound with unique structural features and reactivity, 2,3-Dihydro-5-methyl-4H-1-benzopyran-4-one can be employed in chemical research to explore new reaction pathways, mechanisms, and synthetic strategies. This can lead to the discovery of new compounds with potential applications in various fields, including materials science, agrochemistry, and environmental chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 18385-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,8 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18385-68:
(7*1)+(6*8)+(5*3)+(4*8)+(3*5)+(2*6)+(1*8)=137
137 % 10 = 7
So 18385-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O2/c1-7-3-2-4-9-10(7)8(11)5-6-12-9/h2-4H,5-6H2,1H3
18385-68-7Relevant academic research and scientific papers
Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones
Begum, Ayisha F.,Balasubramanian, Kalpattu K.,Shanmugasundaram, Bhagavathy
, (2021/09/13)
3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.
Preparation method of oxygen heterocyclic compound
-
, (2017/08/29)
The invention discloses a preparation method of an oxygen heterocyclic compound 4-hydroxyl-5-methyl-3,4-dihydro-2H-chromene-4-carboxylic acid. With 4-methylphenol as a start raw material, a target product is prepared by condensation, ring closing, cyaniding, TMS removal and hydrolysis. The compound is an important pharmaceutical intermediate.
