183860-58-4

Upstream product

• 504-29-0 2-aminopyridine 
• 170028-72-5 (3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 2592-95-2 benzotriazol-1-ol 
• 183860-59-5 (3aα,4β,8α,8aβ)-3,3'-[(dihydro-2,2-dimethyl-6-oxo-4,8-bis(phenylmethyl)-4H-1,3-dioxolo[4,5-e][1,3]diazepine-5,7(6H,8H)-diyl)bis(methylene)]bis[benzoic acid] 

Relevant academic research and scientific papers

The kinetics and mechanism of the reaction of p-nitrocumyl bromide with azide ions in dimethyl sulfoxide. Evidence for a heterolytic reaction

The reaction of p-nitrocumyl bromide 1 with azide ions in [2H6]dimethyl sulfoxide does not show the strong photochemical catalysis and inhibition by electron acceptors and radical traps characteristic of the reactions of the corresponding chloride in dipolar aprotic solvents and used as evidence for a SRN1 reaction. Instead, the bromide reacts by a heterolytic mechanism that is approximately first-order with respect to both the substrate and the lithium azide. The results can be interpreted in terms of the preassociation mechanism proposed by Richard and Amyes for the reaction of p-nitrocumyl chloride with azide ions in aqueous trifluoroethanol but there is some evidence for the participation of the azide ion in heterolysis of the C-Br bond.

Nonsymmetrically substituted cyclic urea HIV protease inhibitors

A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis

HIV protease inhibitory bis-benzamide cyclic ureas: A quantitative structure-activity relationship analysis

A series of N,N'-disubstituted cyclic urea 3-benzamides has been synthesized and evaluated for HIV protease inhibition and antiviral activity. Some of these benzamides have been shown to be potent inhibitors of HIV protease with K(i) 90 20 nM for viral replication and, as such, may be useful in the treatment of AIDS. The synthesis and quantitative structure activity relationship for this benzamide series will be discussed.