183882-25-9Relevant academic research and scientific papers
Reactions of trichloromethylarenes with hydrazine derivatives. Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
Poddubnyi,Belen'kii,Krayushkin
, p. 1185 - 1188 (2007/10/03)
The effect of the solvent on the course of the reaction between trichloromethylarenes and thioacylhydrazines or acylhydrazines has been considered. In alcohols as solvents, alkyl arenecarboxylates form as a result of alcoholysis, while 2,5-disubstituted 1,3,4-thiadiazoles (1,3,4-oxadiazoles) form as minor products. In pyridine solutions, the major or sole products are those of reductive condensation, i.e., the corresponding N-substituted hydrazones of arenecarbaldehydes. 1,3,4-Thiadiazole or 1,3,4-oxadiazole derivatives are obtained in good yield when the reaction is carried out in a pyridine - alkanol mixture.
SYNTHESIS OF 2-AMINO-5-ARYL-1,3,4-THIADIAZOLES FROM TRICHLOROMETHYLARENES: THE EFFECT OF REACTION CONDITIONS
Belen'kii, Leonid,Poddubny, Igor,Krayushkin, Mikhaill
, p. 469 - 470 (2007/10/02)
The factors have been considered controlling the course of the interaction between trichloromethylarenes and thioacylhydrazines.
Antihypertensive Thiadiazoles. 1. Synthesis of Some 2-Aryl-5-hydrazino-1,3,4-thiadiazoles with Vasodilator Activity
Turner, Stephen,Myers, Malcolm,Gadie, Brian,Nelson, Anthony J.,Pape, Robin,et al.
, p. 902 - 906 (2007/10/02)
Some 2-Aryl-5-hydrazino-1,3,4-thiadiazoles have been synthesized and screened for antihypertensive activity.In general, compounds with a 2-substituted phenyl ring had higher activity than their 3- or 4-substituted counterparts or those containing heteroar
