183882-53-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 183882-48-6 (R)-2-Amino-hex-5-enoic acid tert-butyl ester 
• 59624-81-6 tert-butyl 2-(((1S,2S,5S)-2-hydroxy-2,6,6-trimethylbicyclo[3.1.1]heptan-3-ylidene)amino)acetate 
• 6456-74-2 Glycine tert-butyl ester 
• 5292-43-3 bromoacetic acid tert-butyl ester 

Downstream Products

• 183882-60-2 (2R,5S)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 183882-59-9 (2R,5R)-5-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 183882-58-8 (R)-5-(tert-Butyl-dimethyl-silanyloxy)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 183882-57-7 (R)-2-Benzyloxycarbonylamino-6-bromo-5-(tert-butyl-dimethyl-silanyloxy)-hexanoic acid tert-butyl ester 
• 183882-56-6 (R)-2-Benzyloxycarbonylamino-6-bromo-5-hydroxy-hexanoic acid tert-butyl ester 
• 183882-55-5 (R)-2-Benzyloxycarbonylamino-4-oxiranyl-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure (2R,5S)- and (2R,5R)-5-hydroxypipecolic acid from glycinate Schiff bases

An asymmetric synthesis of cis- and trans-5-hydroxy-(D)-pipecolic acid, starting from glycinate Schiff bases is described. The approach involves the stereoselective alkylation to generate an unsaturated side chain which on cyclisation leads to the desired trans- or cis-5-hydroxy-(D)-pipecolic acid.