183885-26-9Relevant academic research and scientific papers
Synthesis of laminin hexasaccharide analogue
Ding, Xianglan,Kong, Fanzuo
, p. 915 - 922 (1998)
The synthesis of laminin hexasaccharide analogue di-O-[Gal-β-(1→4)-Glc-β]-(1→2)-(1→6)-man-α- (1→6)-man-α-Me derivative (1) was achieved with 1,2-anhydromannopyranose benzyl ether (3) as the key intermediate. Coupling of 3 with methyl 2,3,4-tri-O-benzyl-α-D-mannopyranoside (4) promoted by ZnCl2 gave methyl 2,3,4-tri-O-benzyl-6-O-(3,4,6-tri-O-benzyl-α-D-mannopyranosyl)-α-D- mannopyranoside (2a). Selective 6-O-debenzylation of 2b with ZnCl2-Ac2O-HOAc followed by coupling with acetobromolactopyranose afforded 1.
Studies on Carbohydrates XX. Synthesis of Hexasaccharide Containing Lactosamine Unit Using Glycosyl Trichloroacetates as Glycosyl Donors
Zhu, Xiao Xiang,Ding, Ping Yu,Cai, Meng Shen
, p. 8549 - 8552 (2007/10/03)
O-Glycosyl trichloroacetate, a stable and readily obtained intermediate, was activated as a highly reactive glycosyl donor upon treatment with acid and coupled with the acceptor to afford complex glycosides with high stereoselectivity. - Key words: disaccharide; hexasaccharide; oligosaccharide; O-glycosyl trichloroacetate; tumor metastasis
Synthesis of tumor-associated saccharides via O-glycosyl trichloroacetic
Zhu, Xiao-Xiang,Ding, Ping Yu,Cai, Meng-Shen
, p. 2833 - 2838 (2007/10/03)
The trichloroacetic method was employed to synthesize di- and hexa-saccharides. O-glycosyl trichloroacetic, a stable and readily obtained intermediate, was activated to give a highly reactive glycosyl donor upon treatment with acid and coupled with the acceptor to afford complex glycosides with high stereoselectivity and in good yield. Two free hexasaccharides will be used to explore the possible prevention of metastatic spread.
