Synthesis of laminin hexasaccharide analogue

Article abstract of DOI:10.1080/07328309808007463

The synthesis of laminin hexasaccharide analogue di-O-[Gal-β-(1→4)-Glc-β]-(1→2)-(1→6)-man-α- (1→6)-man-α-Me derivative (1) was achieved with 1,2-anhydromannopyranose benzyl ether (3) as the key intermediate. Coupling of 3 with methyl 2,3,4-tri-O-benzyl-α-D-mannopyranoside (4) promoted by ZnCl₂ gave methyl 2,3,4-tri-O-benzyl-6-O-(3,4,6-tri-O-benzyl-α-D-mannopyranosyl)-α-D- mannopyranoside (2a). Selective 6-O-debenzylation of 2b with ZnCl₂-Ac₂O-HOAc followed by coupling with acetobromolactopyranose afforded 1.

Full text of DOI:10.1080/07328309808007463

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Journal of Carbohydrate Chemistry
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Synthesis of Laminin Hexasaccharide
Analogue
Xianglan Ding a & Fanzuo Kong a
a Research Center for Eco-Environmental Sciences , Academia
Sinica , P.O.Box 2871, Beijing, 100085, P. R. China
Published online: 18 Aug 2006.
To cite this article: Xianglan Ding & Fanzuo Kong (1998) Synthesis of Laminin Hexasaccharide
Analogue, Journal of Carbohydrate Chemistry, 17:6, 915-922
To link to this article: http://dx.doi.org/10.1080/07328309808007463
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