183892-45-7

Upstream product

• 162052-68-8 3'-O-tert-Butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-formyl-thymidin 
• 162052-67-7 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 139925-90-9 1-[(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 197070-48-7 1-[(2R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(1-hydroxy-propyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Modified nucleotides

The current invention concerns new modified nucleotides that are accepted by reverse transcriptases and incorporated in to a growing oligonucleotide but are not accepted by polymerases. Oligonucleotides comprising the new modified nucleotides can be cleaved photolytically. Also embraced is a process for the synthesis of the new modified nucleotides, and their use.

165. Synthesis of 4′-C-acylated thymidines

Two synthetic pathways towards 4′-C-acylthymidines are presented. These modified mononucleosides are precursors of the 2′-deoxyribonucleotide 4′-C-radical. They were converted into their corresponding 3′-O-[(2-cyanoethyl) N,N-diisopropylphosphoramidites]