162052-68-8

Upstream product

• 162052-67-7 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 139925-90-9 1-[(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 139887-99-3 3'-O-(tert-butyldimethylsilyl)-4'-(hydroxymethyl)-thymidine 

Downstream Products

• 221272-69-1 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-chloro-vinyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 389873-56-7 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(vinyl)thymidine 
• 591754-21-1 5'-O-(4,4'-dimethoxytrityl)-4'-C-(isopropyl)thymidine 
• 591754-22-2 5'-O-(4,4'-dimethoxytrityl)-4'-C-(isobutyl)thymidine 
• 183892-50-4 4'-C-benzoylthymidine 
• 183892-46-8 1-[(2R,4S,5R)-5-Benzoyl-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 183892-68-4 4'-C-benzoyl-5'-O-(4,4'-dimethoxytrityl)thymidine 
• 183892-70-8 5'-O-(4,4'-Dimethoxytrityl)-4'-C-(2,2-dimethylpropanoyl)thymidine 
• 183892-45-7 4'-Propionyl-3'-O-tert-butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-thymidine 
• 183892-66-2 4'-C-acetyl-5'-O-(4,4'-dimethoxytrityl)thymidine 
• 183892-44-6 4'-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-thymidine 
• 389873-57-8 3'-O-(tert-butyldimethylsilyl)-5'-O-(tert-butyldiphenylsilyl)-4'-C-(2-methylpropenyl)thymidine 
• 183892-43-5 1-[(2R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(hydroxy-phenyl-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 183892-47-9 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,2-dimethyl-propionyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Dinucleotides of 4′-C-vinyl- and 5′-C-allylthymidine as substrates for ring-closing metathesis reactions

Thymidine derivatives containing a 4′-C-vinyl group or a 5′-C-allyl group are synthesized and used as building blocks for three different dinucleotides. These are evaluated as substrates for ring-closing metathesis cyclisations, and a protected 5′-C-allyl

Dna polymerase selectivity: Sugar interactions monitored with high-fidelity nucleotides

Do enzyme - sugar interactions contribute to DNA-polymerase fidelity? With the novel chemical probes 1 (R=CH3)2), which are used by a DNA polymerase more selectively than the natural counterpart (R=H), insights are obtained into the

Modified nucleotides

The current invention concerns new modified nucleotides that are accepted by reverse transcriptases and incorporated in to a growing oligonucleotide but are not accepted by polymerases. Oligonucleotides comprising the new modified nucleotides can be cleaved photolytically. Also embraced is a process for the synthesis of the new modified nucleotides, and their use.

165. Synthesis of 4′-C-acylated thymidines

Two synthetic pathways towards 4′-C-acylthymidines are presented. These modified mononucleosides are precursors of the 2′-deoxyribonucleotide 4′-C-radical. They were converted into their corresponding 3′-O-[(2-cyanoethyl) N,N-diisopropylphosphoramidites]