18391-77-0

Usage

General Description

1-methyl-3-phenyl-2-thioxoimidazolidin-4-one, also known as tioxolone, is a chemical compound with the molecular formula C10H11NO2S. It is a derivative of imidazolidine-2-thione and is commonly used in the pharmaceutical industry for its potential as an anti-inflammatory, antiviral, and antifungal agent. Tioxolone has also been studied for its potential as a treatment for acne, psoriasis, and other skin conditions. Its unique structure and properties make it a promising candidate for the development of new drugs and therapies.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 77128-70-2 N-(9-fluorenylmethoxycarbonyl)sarcosine 
• 7647-01-0 hydrogenchloride 
• 52605-49-9 sarcosine ethyl ester hydrochloride 
• 107-97-1 sarcosine 

Downstream Products

• 473739-49-0 1-methyl-3-phenyl-5-[(E)-1-phenylmethylidene]-2-thioxoimidazolidin-4-one 
• 857768-05-9 5-isopropylidene-1-methyl-3-phenyl-2-thioxo-imidazolidin-4-one 
• 1164563-50-1 1-methyl-3-phenyl-5-((E)-2-thienylidene)-2-thiohydantoin 
• 354119-57-6 5-((E)-3,4-methylenedioxybenzylidene)-1-methyl-3-phenyl-2-thiohydantoin 
• 150715-06-3 5-isopropyl-1-methyl-3-phenyl-2-thiohydantoin 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors

We report the synthesis of novel 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins 3, and their biological evaluation using NADPH oxidase (NOX) 1 and 4. Based on structural and pharmacophore analyses of known inhibitors such as hydroxypyrazole 2, we e

Design, Synthesis, and Biological Evaluation of Thio-Containing Compounds with Serum HDL-Cholesterol-Elevating Properties

A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have HDL-elevating properties in several animal models. Concerns about the chemical and metabolic stability of 1

Synthesis of 3-substituted 5-arylidene-1-methyl-2-Thiohydantoins under microwave irradiation

A mono-modal microwave oven was used to expedite the synthesis of small libraries of 3-substituted 1-methyl-2-thiohydantoins and 3-substituted 5-arylidene-1-methyl-2-thiohydantoins. In comparison with the traditional reflux methods, similar or higher yields were obtained.

Sequencing of peptoid peptidomimetics by Edman degradation

The direct identification of resin-bound peptoid peptidomimetics by sequencing is described. The N-terminus of the peptoid was treated with phenyl isothiocyanate, after which the N-terminal peptoid residue was cleaved from the resin as its thiohydantoin derivative. For deduction of the peptoid sequence, the HPLC retention times of the obtained thiohydantoins were compared to those of independently prepared reference thiohydantoins.