Cas 183946-06-7,Benzene, 2-methyl-4-nitro-1-(pentafluoroethyl)-

183946-06-7

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Basic information

Product Name: Benzene, 2-methyl-4-nitro-1-(pentafluoroethyl)-
Synonyms:
CAS NO:183946-06-7
Molecular Formula: C9H6F5NO2
Molecular Weight: 255.144
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Benzene, 2-methyl-4-nitro-1-(pentafluoroethyl)-(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 2-methyl-4-nitro-1-(pentafluoroethyl)-(183946-06-7)
EPA Substance Registry System: Benzene, 2-methyl-4-nitro-1-(pentafluoroethyl)-(183946-06-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 183946-06-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 183946-06-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,9,4 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 183946-06:
(8*1)+(7*8)+(6*3)+(5*9)+(4*4)+(3*6)+(2*0)+(1*6)=167
167 % 10 = 7
So 183946-06-7 is a valid CAS Registry Number.

183946-06-7Upstream product

183946-06-7Downstream Products

183946-06-7Relevant academic research and scientific papers

COMPOUNDS AND METHODS OF USE

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Page/Page column 114, (2010/11/27)

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl- 3-hydroxy. N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and related compounds

Kuo, Elizabeth A.,Hambleton, Philip T.,Kay, David P.,Evans, Phillip L.,Matharu, Saroop S.,Little, Edward,McDowall, Neil,Jones, C. Beth,Hedgecock, Charles J. R.,Yea, Christopher M.,Chan, A. W. Edith,Hairsine, Peter W.,Ager, Ian R.,Tully, W. Roger,Williamson, Richard A.,Westwood, Robert

, p. 4608 - 4621 (2007/10/03)

The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues of the active metabolite 2 have been synthesized. Their in vivo biological activity determined in rat and mouse delayed type hypersensitivity has been found to correlate well with their in vitro DHODH potency. The most promising compound (3) has shown activity in rat and mouse collagen (II)-induced arthritis models (ED50 = 2 and 31 mg/kg, respectively) and has shown a shorter half-life in man when compared with leflunomide. Clinical studies in rheumatoid arthritis are in progress.

3-cycloalkyl-propanamides

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, (2008/06/13)

A compound selected from the group consisting of all tautomeric forms of a cycloalky-propanamide of the formula STR1 wherein R1 is cycloalkyl of 3 to 6 carbon atoms, R2 is hydrogen or alkyl of 1 to 3 carbon atoms, R3, Rsu

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