183957-38-2Relevant academic research and scientific papers
Regioselective nucleophilic ring opening reactions of 2,2-disubstituted aziridines - The asymmetric synthesis of α,α-disubstituted amino acids
Burgaud, Beatrice G. M.,Horwell, David C.,Padova, Allessandro,Pritchard, Martyn C.
, p. 13035 - 13050 (2007/10/03)
In this paper a broadly applicable synthesis of chiral α,α-disubstituted amino acids is outlined based upon regioselective ring opening of aziridine derivatives. Examples of nitrogen, sulphur and carbon nucleophiles were found to preferentially attack the C3 position of chiral 2-methyl-2-silyloxymethyl aziridines to provide a range of α,α-disubstituted amino acid derivatives in good yield.
