183957-41-7

Upstream product

• 183957-34-8 2-Methyl-2-(toluene-4-sulfonylamino)-3-(toluene-4-sulfonyloxy)-propionic acid methyl ester 
• 183957-35-9 methyl 2-methyl-1-tosylaziridine-2-carboxylate 

Downstream Products

• 183957-33-7 2-Methyl-1-(toluene-4-sulfonyl)-aziridine-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

METHOD FOR PRODUCING CARBONYL COMPOUND

PROBLEM TO BE SOLVED: To allow a method that oxidizes a first or second alcohol compound to obtain a carbonyl compound to be conducted with a higher yield than that of a method that uses sodium hypochlorite as an oxidizer. SOLUTION: A first or second alcohol compound is oxidized, in the presence of tetraalkylammonium hypochlorite and, preferably, in coexistence with a nitroxy radical catalyst and a metal halide cocatalyst, to produce a carbonyl compound composed of an aldehyde compound, a carboxylic acid compound, and a ketone compound. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

Regioselective nucleophilic ring opening reactions of 2,2-disubstituted aziridines - The asymmetric synthesis of α,α-disubstituted amino acids

In this paper a broadly applicable synthesis of chiral α,α-disubstituted amino acids is outlined based upon regioselective ring opening of aziridine derivatives. Examples of nitrogen, sulphur and carbon nucleophiles were found to preferentially attack the C3 position of chiral 2-methyl-2-silyloxymethyl aziridines to provide a range of α,α-disubstituted amino acid derivatives in good yield.