183957-35-9Relevant academic research and scientific papers
Aziridination of alkenes using N-iodo-N-potassio-p-toluenesulphonamide as a nitrene precursor
Jain, Suman L.,Sain, Bir
, p. 575 - 577 (2003)
N-Iodo-N-potassio-p-toluenesulphonamide was found to be a convenient nitrene precursor for the aziridination of alkenes in the presence of copper catalysts.
Heterogeneous Olefin Aziridination Reactions Catalyzed by Polymer-Bound Tris(triazolyl)methane Copper Complexes
Rodríguez, Manuel R.,Molina, Francisco,Etayo, Pablo,Pericàs, Miquel A.,Pérez, Pedro J.,Díaz-Requejo, M. Mar
, p. 3727 - 3730 (2021/09/06)
Efficient olefin aziridination has been achieved with a tris(triazolyl)methane copper catalyst supported onto polystyrene. Aryl, alkyl and methoxycarbonyl-substituted olefins are converted into N-tosylaziridines in good to high yields. The solid catalyst is readily separated by filtration and recycled, allowing its reuse with no significant loss of the catalytic activity.
An Electron-Poor Dioxa-[2.1.1]-(2,6)-pyridinophane Ligand and Its Application in Cu-Catalyzed Olefin Aziridination
Yang, Fan,Ruan, Jiaheng,Zavalij, Peter Y.,Vedernikov, Andrei N.
, (2019/11/14)
A novel macrocyclic 1,7-dioxa-[2.1.1]-(2,6)-pyridinophane ligand has been synthesized and crystallographically characterized. Two derived metal complexes, dichloropalladium(II) and chlorocopper(I), were prepared. In the palladium(II) complex LPdCl2/
Design, synthesis, and biological evaluation of CXCR4 ligands
Mona, Christine E.,Besserer-Offroy, élie,Cabana, Jér?me,Leduc, Richard,Lavigne, Pierre,Heveker, Nikolaus,Marsault, éric,Escher, Emanuel
, p. 10298 - 10311 (2016/11/11)
A combination of the CXCR4 inverse agonist T140 with N-terminal CXCL12 oligopeptides has produced the first nanomolar synthetic CXCR4 agonists. In these agonists, the inverse agonistic portion provides affinity whereas the N-terminal CXCL12 sequence induces receptor activation. Several CXCR4 crystal structures exist with either CVX15, an inverse agonist closely related to T140 and IT1t, a small molecule; we therefore attempted to produce another CXCL12 oligopeptide combination with IT1t. For this purpose, a primary amino group was introduced by total synthesis into one of the methyl groups of IT1t, serving as an anchoring point for the oligopeptide graft. The introduction of the oligopeptides on this analog however yielded antagonists, one compound displaying high affinity. On the other hand, the amino-substituted analogue itself proved to be an inverse agonist with a binding affinity of 2.6 nM compared to 11.5 nM for IT1t. This IT1t-like analog is hitherto one of the most potent non-peptidic CXCR4 inverse agonists reported.
Syntheses of acetonitrile ligated copper complexes with perfluoroalkoxy aluminate as counter anion and their catalytic application for olefin aziridination
Li, Yang,Diebl, Bernd,Raith, Alexander,Kühn, Fritz E.
supporting information; body text, p. 5954 - 5956 (2009/04/11)
Acetonitrile ligated copper complexes with perfluoroalkoxy aluminate Al {OC (CF3)3}4- as weakly coordinating counter anion are successfully synthesized. Aziridination of various olefins with PhINTs catalyzed by
An unusual copper catalyzed iodine mediated aziridination of olefins with the direct use of p-toluenesulphonamide
Jain, Suman L.,Sharma, Vishal B.,Sain, Bir
, p. 9 - 13 (2007/10/03)
p-Toluenesulphonamide/I2 was found to be an efficient system for the copper catalyzed aziridination of olefins in good yields under very mild conditions.
A practical, fast, and high-yielding aziridination procedure using simple Cu(II) complexes containing N-donor pyridine-based ligands
Mohr, Fabian,Binfield, Seth A.,Fettinger, James C.,Vedernikov, Andrei N.
, p. 4833 - 4839 (2007/10/03)
Four-coordinate dichlorocopper(II) complexes derived from di(2-pyridyl)methanes or pyridine itself exhibit high catalytic activity in aziridination of regular olefins with PhINTs in weakly coordinating chloroform in the presence of 1-2 equiv of NaBAr
An efficient transition metal-free aziridination of alkenes with Chloramine-T using aqueous H2O2/HBr
Jain, Suman L.,Sharma, Vishal B.,Sain, Bir
, p. 8731 - 8732 (2007/10/03)
The combination of aqueous H2O2 and HBr was found to be an efficient transition metal-free green catalytic system for the aziridination of a variety of alkenes under very mild reaction conditions.
Angular ligand constraint yields an improved olefin aziridination catalyst
Vedernikov, Andrei N.,Caulton, Kenneth G.
, p. 2591 - 2594 (2007/10/03)
(Matrix presented) The use of a pyridinophane, a macrocycle composed of three pyridines linked, via all ortho positions through CH2 or CH2CH2 groups, bound to copper, gives good performance (rate and yield) catalyzing the
