183960-51-2

Upstream product

• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 513-31-5 2-bromoallyl bromide 

Downstream Products

• 183960-68-1 (R)-4-Benzyl-3-{(R)-2-[(2S,4S,5R,6S)-5-methyl-2-phenyl-6-((1S,5R,6S,7S,8R)-1,5,7-trimethyl-3-methylene-4-oxo-6-triethylsilanyloxy-8-triisopropylsilanyloxy-nonyl)-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 183960-89-6 (R)-4-Benzyl-3-{(R)-2-[(2S,4S,5R,6S)-6-((1S,5R,6S,7R,8R)-6-hydroxy-1,5,7-trimethyl-3-methylene-4-oxo-8-triisopropylsilanyloxy-nonyl)-5-methyl-2-phenyl-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 183960-69-2 (R)-4-Benzyl-3-{(R)-2-[(2S,4S,5R,6S)-6-((1S,4S,5R,6R,7R,8R)-4,6-dihydroxy-1,5,7-trimethyl-3-methylene-8-triisopropylsilanyloxy-nonyl)-5-methyl-2-phenyl-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 183960-57-8 (4R)-4-benzyl-3-{(2R)-2-[(2S,4S,5S,6S)-6-((1S)-3-bromo-1-methyl-3-butenyl)-5-methyl-2-phenyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone 
• 183960-80-7 (4R)-4-benzyl-3-((2R,3S,4R,5S,6S)-8-bromo-3,5-dihydroxy-2,4,6-trimethyl-1-oxo-8-nonenyl)-2-oxazolidinone 
• 183960-55-6 (4R)-4-benzyl-3-((2R,4R,5S,6S)-8-bromo-5-hydroxy-2,4,6-trimethyl-1,3-dioxo-8-nonenyl)-2-oxazolidinone 

Relevant academic research and scientific papers

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.